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Description
LILRB4 Recombinant Rabbit mAb (S-2504-22)Product Specification Host Rabbit Antigen LILRB4 Synonyms Leukocyte immunoglobulin like receptor subfamily B member 4; B4; CD85 antigen like family member K; Immunoglobulin like transcript 3 (ILT 3); Leukocyte immunoglobulin like receptor 5 (LIR 5); Monocyte inhibitory receptor HM18; CD85k; ILT3; LIR5 Immunogen Recombinant Protein Location Cell membrane Accession Q8NHJ6 Clone Number S 2504 22 Antibody Type Recombinant mAb Isotype IgG Application WB,
Product Specification
| Host | Rabbit |
| Antigen | LILRB4 |
| Synonyms | Leukocyte immunoglobulin-like receptor subfamily B member 4; B4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3 (ILT-3); Leukocyte immunoglobulin-like receptor 5 (LIR-5); Monocyte inhibitory receptor HM18; CD85k; ILT3; LIR5 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q8NHJ6 |
| Clone Number | S-2504-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | THP-1, HL-60 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| IHC-P | 1:500 | Hu |
Background
LILRB4 (Leukocyte Immunoglobulin-Like Receptor B4), also known as ILT3, is a type I transmembrane protein with two extracellular Ig-like domains and three intracellular ITIM motifs that recruit SHP-1/2 phosphatases to dampen myeloid-cell activation; expressed chiefly on monocytes, macrophages and dendritic cells, it functions as a key immune checkpoint that maintains self-tolerance by inhibiting NF-κB/MAPK signaling, suppressing T-cell proliferation and promoting Treg/Ts differentiation, but is exploited by tumors such as AML through ligands like ApoE to enable immune evasion, leukemia invasion and poor prognosis, making it an emerging therapeutic target in cancer, autoimmunity and transplantation.
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Exchange/Return Notes
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