SKU: 29385082835

Syndecan-1/CD138 His Tag Protein, Human

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Description

Syndecan-1/CD138 His Tag Protein, HumanProduct Specification Species Human Synonyms Syndecan Proteoglycan 1, CD138, SYND1, SDC, Syndecan 1, SDC1 Accession P18827 Amino Acid Sequence Gln23 Gly254, with C terminal 10* His QIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGGGSGGGSHHHHHHHHHH Expression System

Product Specification


Species Human
Synonyms Syndecan Proteoglycan 1, CD138, SYND1, SDC, Syndecan-1, SDC1
Accession P18827
Amino Acid Sequence

Gln23-Gly254, with C-terminal 10* His QIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGGGSGGGSHHHHHHHHHH

Expression System HEK293
Molecular Weight

45kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、Palaiologou M. et al. (2014) CD138 (syndecan-1) expression in health and disease. Histol Histopathol. 29(2): 177-189.

Background

CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans. CD138 is significant for cell-cell and cell-matrix interactions. In adult human tissues, CD138 is predominantly expressed in epithelial cells and plasmacytes. CD138 immunoexpression is altered in a wide spectrum of benign inflammatory, infectious and fibrotic diseases (colitis, allergic contact dermatitis, fibrosis of various organs, etc) and diabetes mellitus type II. Furthermore, CD138 is involved in molecular pathways that are deregulated during carcinogenesis and are related to cell proliferation, apoptosis, angiogenesis, tumour invasion and metastasis.CD138 tumour cell and stromal immunoexpression is modified in various types of cancer, and is frequently correlated with clinicopathological parameters and patients' prognosis. The soluble form of CD138 may be used as a prognostic serum biomarker with promising results in respiratory tract carcinomas. CD138 plays a crucial role in carcinogenesis and is an attractive target for anticancer treatment with heparanase inhibitors and anti-CD138 antibodies for immunotherapy.

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SKU: 29385082835

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4.8 ★★★★★
Based on 14 reviews
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C
Verified Purchase
CV
Omaha, US
★★★★★ 2
Not for aggressive chewers
My 14 pound puppy chewed a big chunk out within 30 minutes. Would not recommend if you have a dog that likes to tear into things
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 30, 2026
G
Verified Purchase
Gail Plaut
Waukegan, US
★★★★★ 1
Not for aggressive chewers as labeled; poor quality
Really disappointed in this item. My barely 16 lb., 1 1/2 yr old labradoodle chewed right thru the plastic in literally 6 seconds. I was going to toss it but at $18, the item should live up to its description-this toothbrush toy is rated 80% on the aggressive chew scale as per packaging…NOT AT ALL! She bit off a couple off chunks immediately, then proceeded to bite off the spikes…couldn’t believe how quickly the toy was destroyed & I took it away within moments of giving it to her.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 10, 2026
A
Verified Purchase
AMAZONCUSTOMER
West Palm Beach, US
★★★★★ 5
great for my dog
my 1 y/o pomeranian won’t let me brush her teeth. she also needs a lot of enrichment. i love putting a dollop of toothpaste, some wet food & few pieces of kibble in this toy for her. it keeps her busy for about 10 minutes and she really enjoys playing with it while consuming everything she can out of it. wonderful way to enrich while giving dental care. she is also a pretty good chewer and it’s still in one piece!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 7, 2026
M
Verified Purchase
Ms. Marie
Dallas, US
★★★★★ 5
Great Product!
Size: Medium, Color: green, orange, pink, Pattern Name: clean tuff bone bacon
My dogs love their dental chews! This product is durable and the perfect size for each of my dogs. I've purchased two of them (medium and large). One of my dogs is an aggressive chewer and this product is holding up. Hartz makes great pet products. I'm very happy with the product.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 30, 2026
S
Verified Purchase
Sumerr Scott
Massapequa, US
★★★★★ 5
Good quality
Size: Extra Small, Color: blue, purple, Pattern Name: clean tuff bone bacon
My dogs favorite toy. It’s so small and cute lol it’s lightweight and easy for her to chew. The quality is great, it’s lasting and no broken pieces.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 18, 2026

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