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Description
Mouse Anti-Human CD223 Antibody (S-R661)Product Specification Host Mouse Antigen CD223 Synonyms Lymphocyte activation gene 3 protein; LAG 3Cleaved into 1 chainsSecreted lymphocyte activation gene 3 protein Curated (sLAG 3); FDC; LAG3 Location Cell membrane Accession P18627 Clone Number S R661 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability
Product Specification
| Host | Mouse |
| Antigen | CD223 |
| Synonyms | Lymphocyte activation gene 3 protein; LAG-3Cleaved into 1 chainsSecreted lymphocyte activation gene 3 protein Curated (sLAG-3); FDC; LAG3 |
| Location | Cell membrane |
| Accession | P18627 |
| Clone Number | S-R661 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD223, also known as LAG-3 (lymphocyte-activation gene 3), is a 70 kDa type I transmembrane glycoprotein expressed on activated CD4⁺ and CD8⁺ T cells, regulatory T cells, NK cells and plasmacytoid dendritic cells; it contains four extracellular Ig-like domains that bind MHC class II with roughly 1 000-fold higher affinity than CD4, a connecting peptide cleaved by ADAM10/17 to release soluble LAG-3, and a cytoplasmic tail with an EP repeat and an ITIM-like motif that delivers inhibitory signals by displacing LCK from the CD4/CD8 coreceptor, thereby attenuating TCR signaling, limiting T-cell proliferation, promoting exhaustion in chronic viral infections and tumors, and enhancing the suppressive function of Tregs, making it the third clinically targeted immune checkpoint receptor after CTLA-4 and PD-1.
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