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Description
IL-21 Recombinant Rabbit mAb (SDT-768-206-2)Product Specification Host Rabbit Antigen IL 21 Synonyms Interleukin 21 Immunogen Recombinant Protein Accession Q9HBE4 Clone Number SDT 768 206 2 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against IL 2 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | IL-21 |
| Synonyms | Interleukin-21 |
| Immunogen | Recombinant Protein |
| Accession | Q9HBE4 |
| Clone Number | SDT-768-206-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against IL-2 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Interleukin-21 (IL-21) is a four-α-helical-bundle type I cytokine produced mainly by activated CD4⁺ T helper cells, NKT cells and TFH cells that signals through a heterodimeric receptor composed of the IL-21R and the common γ-chain (γc) to activate JAK1/JAK3–STAT1/STAT3 pathways, thereby orchestrating a broad immunomodulatory program that drives the differentiation, proliferation and effector function of B cells into long-lived plasma cells and memory B cells, promotes the development of Th17 and Tfh subsets while suppressing Treg stability, enhances cytotoxic activity and survival of CD8⁺ T cells and NK cells, and synergizes with IFN-γ or IL-15 to amplify antiviral and antitumor immunity, making it a key molecular hub whose dysregulation contributes to autoimmune pathologies such as systemic lupus erythematosus and type 1 diabetes and whose exogenous delivery or blockade is being therapeutically exploited in cancer immunotherapy, chronic viral infections and allergy.
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