SKU: 34317436593

CaV2.3 (CACNA1E) Recombinant Rabbit mAb (S-3244-59)

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Description

CaV2.3 (CACNA1E) Recombinant Rabbit mAb (S-3244-59)Product Specification Host Rabbit Antigen CaV2. 3 (CACNA1E) Synonyms Voltage dependent R type calcium channel subunit alpha 1E; Brain calcium channel II (BII); Calcium channel; L type; alpha 1 polypeptide; isoform 6; Voltage gated calcium channel subunit alpha Cav2. 3; CACH6; CACNL1A6 Immunogen Synthetic Peptide Location Membrane Accession Q15878 Clone Number S 3244 59 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt

Product Specification


Host Rabbit
Antigen CaV2.3 (CACNA1E)
Synonyms Voltage-dependent R-type calcium channel subunit alpha-1E; Brain calcium channel II (BII); Calcium channel; L type; alpha-1 polypeptide; isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3; CACH6; CACNL1A6
Immunogen Synthetic Peptide
Location Membrane
Accession Q15878
Clone Number S-3244-59
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Ms, Rt
Positive Sample mouse brain, rat brain
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Ms, Rt
IHC-P 1:2000 Ms, Rt

Background

CaV2.3, encoded by the CACNA1E gene, is a member of the high-voltage-activated (HVA) R-type calcium channel family, distinguished by its unique biophysical properties including rapid activation and inactivation kinetics, single-channel conductance, and insensitivity to conventional dihydropyridine, ω-conotoxin GVIA, or ω-agatoxin IVA blockers. Predominantly expressed in the central nervous system—particularly in the cortex, hippocampus, cerebellum, and thalamus—this channel plays a critical role in regulating neuronal excitability, neurotransmitter release at specialized synapses, and synaptic plasticity. Functionally, CaV2.3 channels contribute to action potential repolarization, afterhyperpolarization, and pacemaking activities in specific neuronal populations, while also modulating calcium signaling pathways that influence gene transcription and neuronal survival. Clinically, gain-of-function mutations in CACNA1E have been associated with developmental and epileptic encephalopathies, autism spectrum disorders, and chronic pain conditions, whereas the channel represents a potential therapeutic target for epilepsy, neuropathic pain, and neurodegenerative diseases due to its distinct pharmacological profile and restricted neuronal distribution.

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SKU: 34317436593

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Whale
Cuba, US
★★★★★ 5
Nice daily use paper for ink jet printers. A good white rating too. OK for occasional color
Size: 1 Ream | 500 Sheets, Style: Letter (8.5x11)
Very good paper for daily use on ink jet printers. Good price, fast deliver, and packaged well. It even works well for color printing but not what you want for high quality glossy color prints.
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Reviewed in the United States on May 30, 2026
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Gabriel L. De Mattos
Omaha, US
★★★★★ 5
Reliable everyday printer paper, no jams and clean prints
Size: 1 Ream | 500 Sheets, Style: Letter (8.5x11)
Standard printer paper that just works. Feeds consistently without jamming across multiple printers I use it in. The brightness level is good and text prints crisp and clear. The 500 sheet ream is a reasonable size to keep on hand. Nothing fancy to say here, it is just reliable paper at a fair price. Amazon Basics has been consistently good for these kinds of commodity items.
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Reviewed in the United States on May 5, 2026
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HONEST REVIEWER
Grantham, US
★★★★★ 4
If you're looking for a budget-friendly option for everyday printing, this is a solid choice.
Size: 1 Ream | 500 Sheets, Style: Letter (8.5x11)
Let's be honest, reviewing copy paper isn't exactly thrilling. But,et's be honest, reviewing copy paper isn't exactly thrilling. But, if you're buying paper, you expect it to, well, work like paper. And in that regard, the Amazon Basics Multipurpose Copy Paper delivers. It works as paper should. That's really the core of it. This paper is functional. It's the kind of paper you buy when you need a lot of it without breaking the bank. Here's a quick breakdown: Pros: Affordable: This is the biggest selling point. If you're looking for a budget-friendly option for everyday printing, this is a solid choice. Good for High-Volume Printing: Because of its affordability, it's great for those situations where you're churning out documents and don't want to worry about the cost per page. Works in Most Printers: I've used it in inkjet and laser printers without any major issues. It's generally reliable in terms of feeding and printing. Acceptable Brightness: It's not the brightest white paper on the market, but it's acceptable for most general-purpose printing. Cons: Not Premium Quality: Don't expect a luxurious feel or exceptionally crisp print quality. It's not designed for high-resolution photos or important presentations. Can Be a Little Thin: Compared to more expensive paper, it can feel a bit thinner. This might lead to slight show-through if you're printing heavily on both sides. Packaging Can Sometimes Be Damaged: While not always the case, some users have reported damaged packaging upon delivery. This hasn't affected the paper itself in my experience, but it's something to be aware of. Overall: The Amazon Basics Multipurpose Copy Paper is a reliable and affordable option for everyday printing needs. It's not fancy, but it gets the job done. If you're looking for premium quality, look elsewhere. But if you just need a lot of paper, that works as paper should, and at a good price, this is a worthwhile choice. That's really the core of it. This paper is functional. It's the kind of paper you buy when you need a lot of it without breaking the bank. Here's a quick breakdown: Pros: Affordable: This is the biggest selling point. If you're looking for a budget-friendly option for everyday printing, this is a solid choice. Good for High-Volume Printing: Because of its affordability, it's great for those situations where you're churning out documents and don't want to worry about the cost per page. Works in Most Printers: I've used it in inkjet and laser printers without any major issues. It's generally reliable in terms of feeding and printing. Acceptable Brightness: It's not the brightest white paper on the market, but it's acceptable for most general-purpose printing. Cons: Not Premium Quality: Don't expect a luxurious feel or exceptionally crisp print quality. It's not designed for high-resolution photos or important presentations. Can Be a Little Thin: Compared to more expensive paper, it can feel a bit thinner. This might lead to slight show-through if you're printing heavily on both sides. Packaging Can Sometimes Be Damaged: While not always the case, some users have reported damaged packaging upon delivery. This hasn't affected the paper itself in my experience, but it's something to be aware of. Overall: The Amazon Basics Multipurpose Copy Paper is a reliable and affordable option for everyday printing needs. It's not fancy, but it gets the job done. If you're looking for premium quality, look elsewhere. But if you just need a lot of paper, that works as paper should, and at a good price, this is a worthwhile choice.
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Reviewed in the United States on April 27, 2025
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Liz
Battle Creek, US
★★★★★ 5
Reliable Everyday Printer Paper
Size: 1 Ream | 500 Sheets, Style: Letter (8.5x11)
This is standard plain printer paper for everyday home use, and it does exactly what it’s supposed to do without any issues. I have had no problems with paper jams, ink smudging, or feeding through the printer. The paper is an average thickness, nothing special, but perfectly fine for printing documents. The color is white. It does not curl, and everything comes out clean and readable. It does not stand out in any particular way, but there is also nothing to complain about. Overall, it is reliable, consistent, and works well for regular home printing needs. I will buy again.
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Reviewed in the United States on May 29, 2026
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Stephen Houston
Lexington, US
★★★★★ 5
Good price. Good paper.
Size: 8 Reams | 4000 Sheets, Style: Letter (8.5x11)
I feel like I have purchased this paper a hundred times. I have it on subscription. It works great in all my printers.
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Reviewed in the United States on May 30, 2026

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