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Description
B7-H7/HHLA2 His Tag Protein, HumanProduct Specification Species Human Synonyms B7 H7, HHLA2, B7 Homolog 7 Accession Q9UM44 Amino Acid Sequence Ile23 Asn344, with C terminal 8*His
Product Specification
| Species | Human |
| Synonyms | B7-H7, HHLA2, B7 Homolog 7 |
| Accession | Q9UM44 |
| Amino Acid Sequence | Ile23-Asn344, with C-terminal 8*His IFPLAFFIYVPMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDSYKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKVGVFLTPVMKYEKRNTNSFLICSVLSVYPRPIITWKMDNTPISENNMEETGSLDSFSINSPLNITGSNSSYECTIENSLLKQTWTGRWTMKDGLHKMQSEHVSLSCQPVNDYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIINESRFSWNKELINQSDFSMNLMDLNLSDSGEYLCNISSDEYTLLTIHTVHVEPSQETASHNGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 51-67kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Zhu Y. et al. (2013) B7-H5 costimulates human T cells via CD28H. Nat Commun. 4: 2043. 2、Dong Z. et al. (2018) EGFR may participate in immune evasion through regulation of B7-H5 expression in non-small cell lung carcinoma. Mol Med Rep. 18: 3769-3779. |
Background
Human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2; also known as B7H7 or B7H5) is the only member of the B7 protein family found in humans. HHLA2 cannot be found in mice and is mainly expressed in human breast, lung, thyroid, melanoma, pancreas, ovary, liver, bladder, colon, prostate, kidney and esophagus cancer cells, activated myeloid cells, monocyte-derived macrophages and dendritic cells. In addition, HHLA2 interacts with the co-receptor CD28H to stimulate T cell proliferation, differentiation and the production of cytokines, including IFN-γ, IL-2 and IL-10. In terms of cancer, higher expression levels of HHLA2 were previously reported to be associated with poorer prognoses or higher degrees of tumour invasion in lung carcinoma, hepatocellular carcinoma and prostate cancer.
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4.6 ★★★★★
Based on 18 reviews
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Product Reviews
★★★★★ 5
Great for Subaru oil consumption
Number of Items: 1, Number of Items: 1
Got this for my 2015 Subaru outback for its notorious oil consumption. It seems to be doing the trick causing less oil consumption after 1k miles noticable difference for sure.
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Reviewed in the United States on January 4, 2026
★★★★★ 5
great for any engin
Size: 12 fl. oz. (Pack of 1)
Have been looking for this for a long time.i always used when i had a ,chevy 327,300.3speed.the engin always run great and when we changed the value cover gaskests the inside look like brand new,and clean.
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Reviewed in the United States on May 31, 2026
★★★★★ 5
Great product
Size: 12 fl. oz. (Pack of 1)
Noticeable difference in the first 50 miles .
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Reviewed in the United States on March 30, 2026
★★★★★ 5
Great product!
Size: 12 fl. oz. (Pack of 1)
Would recommend pouring oil into container after pouring in and shaking it up, great additive recommended by some old folks but I would have to say it’s just thick as molasses. Used in 2016 FORD F150 5.0 V8
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Reviewed in the United States on April 3, 2025
★★★★★ 5
Great product!
Size: 12 fl. oz. (Pack of 1)
My Dad believed in Bardaul and I do to!
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Reviewed in the United States on January 22, 2025