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Description
GPD2 Recombinant Rabbit mAb (S-2941-41)Product Specification Host Rabbit Antigen GPD2 Synonyms Glycerol 3 phosphate dehydrogenase, mitochondrial; GPD M; GPDH M; mitohondrial glycerophosphate dehydrogenase gene (mGDH); mtGPD Immunogen Synthetic Peptide Location Mitochondrion Accession P43304 Clone Number S 2941 41 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, MCF7, U 87 MG, Caco 2, LNCaP, NIH 3T3, mouse skeletal muscle, C6,
Product Specification
| Host | Rabbit |
| Antigen | GPD2 |
| Synonyms | Glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; GPDH-M; mitohondrial glycerophosphate dehydrogenase gene (mGDH); mtGPD |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P43304 |
| Clone Number | S-2941-41 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, MCF7, U-87 MG, Caco-2, LNCaP, NIH/3T3, mouse skeletal muscle, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu |
Background
GPD2 (glycerol-3-phosphate dehydrogenase 2, mitochondrial) is a 727-amino-acid, FAD-binding inner-mitochondrial-membrane enzyme that catalyzes the irreversible oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons into the respiratory chain at coenzyme Q and thereby serving as the rate-limiting component of the glycerol-phosphate shuttle that re-oxidizes cytosolic NADH to sustain glycolysis; it is expressed ubiquitously, its activity modulates glucose-stimulated insulin secretion, reactive-oxygen-species generation, platelet activation and bleeding risk, and its gene (chr2q24.1) produces two transcripts encoding the same protein.
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