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Description
Biotin Mouse Anti-Human CD124 Antibody (S-3171)Product Specification Host Mouse Antigen CD124 Synonyms Interleukin 4 receptor subunit alpha; IL 4 receptor subunit alpha; IL 4R subunit alpha; IL 4R alpha; IL 4RA; IL4R; IL4RA Location Cell membrane Accession P24394 Clone Number S 3171 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability
Product Specification
| Host | Mouse |
| Antigen | CD124 |
| Synonyms | Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4R; IL4RA |
| Location | Cell membrane |
| Accession | P24394 |
| Clone Number | S-3171 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD124, also known as the interleukin-4 receptor alpha chain (IL-4Rα), is a member of the cytokine receptor superfamily and a key component of Type II cytokine receptors. It primarily functions by forming two distinct types of receptors through pairing with different chains: Type I receptor is composed of CD124 and the common gamma chain (γc), primarily mediating IL-4 signal transduction; the Type II receptor is formed by CD124 and the interleukin-13 receptor alpha 1 chain (IL-13Rα1), which can mediate signals for both IL-4 and IL-13. CD124 plays a central role in activating the JAK-STAT signaling pathway (particularly STAT6), thereby regulating the proliferation, differentiation, and antibody class switching of B cells and T cells, as well as macrophage polarization. It is critically important in allergic responses, inflammation, anti-parasitic immunity, and the tumor microenvironment. Dysregulation of its function is closely associated with allergic diseases such as asthma and atopic dermatitis, as well as certain autoimmune disorders and cancers.
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