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Description
Human TNF-α Onestep ELISA KitProduct Specification Antigen TNF Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 8% Inter assay: 4. 7% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 1. 446 pg mL Range 7. 813 pg mL 500 pg mL Recovery Cell culture supernatant: 109%
Product Specification
| Antigen | TNF-α |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.8%； Inter-assay: 4.7% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 1.446 pg/mL |
| Range | 7.813 pg/mL – 500 pg/mL |
| Recovery | Cell culture supernatant: 109% Serum: 102% Plasma: 94% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
TNF-α, which stands for Tumor Necrosis Factor-alpha, is a potent signaling molecule crucial for immune system regulation. It is primarily produced by activated macrophages, but also by other immune cells like T lymphocytes and mast cells. Its main role is to orchestrate inflammation, a key defense mechanism against infection and injury. TNF-α promotes the activation of immune cells and induces fever by acting on the hypothalamus. Furthermore, it can trigger programmed cell death (apoptosis) in certain tumor cells, which is how it earned its name. While essential for host defense, excessive or chronic production of TNF-α is a major driver of inflammatory diseases, such as rheumatoid arthritis and Crohn's disease. This has made it a critical therapeutic target, with drugs blocking TNF-α being widely used. In essence, TNF-α is a master regulator of inflammation, with powerful but potentially harmful effects that must be tightly controlled.
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Exchange/Return Notes
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