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Description
FXR Recombinant Rabbit mAb (S-2845-71)Product Specification Host Rabbit Antigen FXR Synonyms Bile acid receptor; Farnesoid X activated receptor; Farnesol receptor HRR 1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor interacting protein 14 (RXR interacting protein 14); BAR; HRR1; RIP14; NR1H4 Immunogen Synthetic Peptide Location Nucleus Accession Q96RI1 Clone Number S 2845 71 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample 293T,
Product Specification
| Host | Rabbit |
| Antigen | FXR |
| Synonyms | Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14 (RXR-interacting protein 14); BAR; HRR1; RIP14; NR1H4 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q96RI1 |
| Clone Number | S-2845-71 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | 293T, HepG2, MCF7, MDA-MB-231, A431, HeLa, A549, HCT 116 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
The Farnesoid X receptor (FXR, NR1H4) is a ligand-activated nuclear receptor that functions as the master bile-acid sensor: after binding physiological bile acids such as chenodeoxycholic acid, FXR heterodimerizes with RXR, translocates to DNA FXR-response elements and trans-activates or represses genes that control bile-acid synthesis (CYP7A1), conjugation (BACS, BAAT), export pumps (BSEP, MRP2) and intestinal re-uptake (IBABP, ASBT), while additionally regulating lipid and glucose metabolism, hepatic lipogenesis, energy balance, inflammatory signaling, gut barrier integrity and innate immunity; FXR exists as four human isoforms (α1–α4) and is expressed mainly in liver, intestine and kidney, with synthetic agonists (e.g. GW4064, obeticholic acid) and antagonists under intense investigation for treating cholestasis, NASH, fibrosis, diabetes and intestinal inflammatory disorders.
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