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Description
Paxillin Recombinant Rabbit mAb (S-619-12)Product Specification Host Rabbit Antigen Paxillin Synonyms PXN Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession P49023 Clone Number S 619 12 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IP Reactivity Hu, Ms, Rt Predicted Reactivity Or, Ms, Rt, Av Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | Paxillin |
| Synonyms | PXN |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P49023 |
| Clone Number | S-619-12 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or, Ms, Rt, Av |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:2000 | |
| IP | 1:50 |
Background
Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Paxillin has been shown to have a clinically-significant role in patients with several cancer types. Enhanced expression of paxillin has been detected in premalignant areas of hyperplasia, squamous metaplasia and goblet cell metaplasia, as well as dysplastic lesions and carcinoma in high-risk patients with lung adenocarcinoma. Mutations in PXN have been associated with enhanced tumor growth, cell proliferation, and invasion in lung cancer tissues.
Shipping Notes
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Exchange/Return Notes
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