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Description
Alexa Fluor® 647 Rat Anti-Mouse CD107b (Mac-3) Antibody (S-R710)Product Specification Host Rat Antigen CD107b Synonyms Lysosome associated membrane glycoprotein 2; LAMP 2; Lysosome associated membrane protein 2; CD107 antigen like family member B; Lysosomal membrane glycoprotein type B (LGP B); Lamp2 Location Lysosome, Endosome, Cell membrane Accession P17047 Clone Number S R710 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample BALB c mouse peritoneal exudates cells Purification
Product Specification
| Host | Rat |
| Antigen | CD107b |
| Synonyms | Lysosome-associated membrane glycoprotein 2; LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; Lysosomal membrane glycoprotein type B (LGP-B); Lamp2 |
| Location | Lysosome, Endosome, Cell membrane |
| Accession | P17047 |
| Clone Number | S-R710 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD107b, also known as lysosome-associated membrane protein 2 (LAMP-2), is a highly glycosylated type I transmembrane protein with a molecular weight of approximately 105–120 kDa. It is primarily located in the lysosomal/endosomal membranes of nearly all cells and can be transiently expressed on the surface of activated platelets, activated lymphocytes, and some tumor cell lines. LAMP-2 plays crucial roles in various cellular processes, including cell adhesion, cellular homeostasis, autophagocytosis, antigen presentation, and protection of the lysosome. Additionally, it may be involved in tumor cell metastasis by mediating adhesion to vascular endothelium.
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