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Description
Biotinylated LILRB3/CD85a/LIT5 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LILRB3, CD85a, ILT5 Accession O75022 Amino Acid Sequence Gly24 Glu443, with C terminal human IgG1 Fc&Avi tag
Product Specification
| Species | Human |
| Synonyms | LILRB3, CD85a, ILT5 |
| Accession | O75022 |
| Amino Acid Sequence | Gly24-Glu443, with C-terminal human IgG1 Fc&Avi tag GPFPKPTLWAEPGSVISWGSPVTIWCQGSQEAQEYRLHKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLEMVMTGAYSKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSRGFQALFPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILPSGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYNRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSPSNGGQYRCYGAHNLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSHPSEPLELVVSGHSGGSSLPPTGPPSTPGLGRYLEIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 85-95kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Kang X. et al. (2016) Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors. Cell Cycle. 15(1): 25-40. |
Background
LILRB3 is a member of LILRB family that is restrictively expressed on myeloid cells, including monocytes, neutrophils, eosinophils, and basophils (as well as on in vitro differentiated mast cells and osteoclasts). LILRB3 contains four cytoplasmic ITIM motifs hat may contribute to negative regulation of immune response. Ligation of LILRB3 in human myeloid cells led to inhibition of immune activation. LILRB3 may be an inhibitor of allergic inflammation and autoimmunity. However, the ligand for LILRB3 has not been identified, and the downstream signaling of LILRB3 is unclear. It is noteworthy that LILRBs, including LILRB3, are primate specific.
LILRB3 is also expressed on some myeloid leukemia, B lymphoid leukemia, and myeloma cells. It is reportedly co-expressed with stem cell marker CD34 and with myeloma marker CD138.
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4.6 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 5
Great Invention
Color: White, Color: White
So simple to install and we absolutely love having this light on our patio table. You can adjust this light anywhere on the pole and direct the lights to shine up or down depending on your preference. It also has three settings. It is well made and runs on 4 AA batteries. This is a great invention and several people that have seen this light have ordered one for their own patio tables.
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Reviewed in the United States on June 18, 2023
★★★★★ 5
Bright, easy to use
Color: White
Love that you have different light settings. Perfect lighting. Fit easy and perfect. Only downfall is you need 4 batteries. Not had it long enough to know how long it will last. Would buy again.
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Reviewed in the United States on July 24, 2023
★★★★★ 5
Brite light fits umbrella well.
Color: White
Great little light, lights up the table great. much better price than the local department stores. time will tell how it holds up but it seems to be built fairly well, also time will tell how long the 4 AA batteries last before they will need changed but all in all I am happy.
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Reviewed in the United States on April 18, 2024
★★★★★ 5
Very Bright, Easy to Put Up / Take Down
Color: White, Color: White
This light is very bright, and more than meets our needs. In addition, it has a nice easy to use latch that allows you to quickly put it on and take it off. It takes 4 batteries, which is a bit more than most, but given the brightness and number of LEDs, it seems to make sense. So far, we’re beyond thrilled to have such an affordable option that made our patio more usable at night.
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Reviewed in the United States on May 2, 2021
★★★★★ 3
Whish it was brighter
Color: White
It is ok, but I thought it would illuminate better.
It provided some light right underneath, but it does not open up more lighting around. It barely expends to the whole length of the table.
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Reviewed in the United States on October 4, 2024