SKU: 39866833439

VEGF Receptor 2/FLK-1 Recombinant Rabbit mAb ，PBS Only(SDT-1519-144)

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Description

VEGF Receptor 2/FLK-1 Recombinant Rabbit mAb ，PBS Only(SDT-1519-144)Product Specification Host Rabbit Antigen VEGF Receptor 2 Synonyms Vascular endothelial growth factor receptor 2; VEGFR 2; Fetal liver kinase 1 (FLK 1); Kinase insert domain receptor (KDR); Protein tyrosine kinase receptor flk 1; CD309; FLK1; VEGFR2; KDR Immunogen Recombinant Protein Location Cell membrane, Endoplasmic reticulum, Cell junction Accession P35968 Clone Number SDT 1519 144 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P

Product Specification


Host Rabbit
Antigen VEGF Receptor 2
Synonyms Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1 (FLK-1); Kinase insert domain receptor (KDR); Protein-tyrosine kinase receptor flk-1; CD309; FLK1; VEGFR2; KDR
Immunogen Recombinant Protein
Location Cell membrane, Endoplasmic reticulum, Cell junction
Accession P35968
Clone Number SDT-1519-144
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample HUVEC
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS
Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu, Ms, Rt

Background

VEGF Receptor 2 (VEGFR-2), also known as KDR in humans and Flk-1 in mice, is a crucial receptor tyrosine kinase that plays a central role in angiogenesis, the formation of new blood vessels. This receptor has high affinity for VEGF-A and mediates most of the endothelial growth, migration, and survival signals induced by VEGF-A. Structurally, VEGFR-2 is a glycosylated transmembrane protein with a molecular weight of about 230 kDa, consisting of an extracellular domain (ECD) for ligand binding, a transmembrane domain (TMD), a juxtamembrane domain (JMD), a tyrosine kinase domain (TKD), and a C-terminal domain (CTD) for signaling. Upon binding to VEGF-A, VEGFR-2 undergoes dimerization and autophosphorylation, activating downstream signaling pathways such as the PLCγ-PKC-MAPK pathway, which promotes endothelial cell proliferation, migration, and vascular permeability. VEGFR-2 is widely expressed in vascular endothelial cells and is also found in some tumor cells, making it a key target for both pro-angiogenic therapies in conditions like ischemic diseases and anti-angiogenic therapies in cancer.

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SKU: 39866833439

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4.3 ★★★★★
Based on 8 reviews
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Verified Purchase
Lucas Crow
Belleville, US
★★★★★ 5
Fantastic for the money
I use this watch at work, so about 40 hours a week I wear it. I work outside in a commonly rainy area, and it's not uncommon for the watch to get wet. I've had it for a couple months or so now, and it really works great! Honestly all of the complaints I have about it can be fixed solely by looking at the price. The viewing angle isn't fantastic - it's a $13 watch. It does lose a little bit of time (a second or two within a week, maybe) - it's a $13 watch. The band is a bit uncomfortable (though it does hold very well, and has lots of size options) - it's a $13 watch. Those are minor things. Here's the good stuff. -Super easy to read -Very easy to use and set -Multiple features -Is genuinely waterproof. I haven't held it underwater, or anything, but for what I would consider 'average' use, it is perfectly waterproof. -Has an adjustable band that doesn't fall off -Fairly tough. I don't treat mine very well and it's held up perfectly fine so far. -It's cheap!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 21, 2019
S
Verified Purchase
S. Murray
Carnegie, US
★★★★★ 4
Cheap Gshock replacement, good value
For $13 this is a steal. It's essentially a casio illuminator w larger bright dial, press once for 5 sec of light then goes dark. Date, time (12 and 24hr), stop watch. The basics, all I needed. A+ Edit: updated the waterproofing is non-existent. It's not even water resistant so treat accordingly don't bring into the shower. The face plastic cracked on me from moderate use, still legible and since I don't test it with water not an issue. The buttons are very sensitive so activities like lifting can cause the bottom left button to depress and switch to stopwatch, or engage the stopwatch. After over a year use I still rank this as a good value. It does the one thing I wish Casio would do is improve light illumination time. The buttons depress easier than Casio's which is a bonus imo, but can be aggravating to some. The water resistance doesn't exist so purchase accordingly.
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Reviewed in the United States on November 29, 2023
G
Verified Purchase
Garrett Mitchell
Lowell, US
★★★★★ 5
Great watch, wristband wears out after a while. Uses a Skmei 1251 band.
Watch is reliable, doesn't drift in time too much, very efficient on battery, has gotten complimented on the look a few times and has a nice user interface. It's also great to be able to see the date without pressing any buttons. The band has fatigued and snapped after many months of putting on and taking off the watch, but If you'd like to find a replacement band, search for Skmei 1251 wristbands.
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Reviewed in the United States on June 8, 2025
A
Verified Purchase
Amazon Customer
Lowell, US
★★★★★ 5
Inexpensive sports watch that was easy to set up and works well.
I have had this watch for a few days. The included instructions were very basic, but I figured out how to set everything up pretty easily. The watch band is pretty adjustable, fits my fairly wide wrists very well. For the price, about half the cost of the name brand very similar watch it replaced, the watch works well, I am very pleased.
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Reviewed in the United States on February 22, 2026
B
Verified Purchase
BucksOnly
Port Orchard, US
★★★★★ 5
This is a great watch for the price!
I purchased this watch to use mostly down at my cabin. It is well-made, the functions are easy to use, and it has withstood all the abuse I’ve put it through. I wear this while hunting, cutting firewood, riding ATVs, and just running around the timber. If I destroy this watch in six months, it will be well worth the money I paid for it, but I don’t think that’s going happen. It’s stylish enough to wear to the office and just going out. If you’re looking for an every day watch, you’re not worried about destroying, this is the one to get.
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Reviewed in the United States on December 11, 2023

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