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Description
HOPX Recombinant Rabbit mAb (S-2087-269)Product Specification Host Rabbit Antigen HOPX Synonyms Homeodomain only protein; Lung cancer associated Y protein; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1; HOD; HOP; LAGY; NECC1; OB1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q9BPY8 Clone Number S 2087 269 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms, Rt Positive Sample mouse brain, rat brain Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | HOPX |
| Synonyms | Homeodomain-only protein; Lung cancer-associated Y protein; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1; HOD; HOP; LAGY; NECC1; OB1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q9BPY8 |
| Clone Number | S-2087-269 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms, Rt |
| Positive Sample | mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms, Rt |
Background
HOPX (homeodomain-only protein) is a 73-amino-acid transcriptional co-factor that contains an atypical homeodomain lacking residues required for DNA binding; instead, it modulates gene expression by interacting with partners such as serum response factor (SRF) to regulate cardiac development, stem-cell fate, and differentiation in multiple tissues. Expressed in embryonic and adult stem cells (e.g., hippocampal neural stem cells), HOPX acts as a tumor suppressor whose loss or silencing is common in cancers (e.g., choriocarcinoma, lung, head and neck squamous carcinoma, and esophageal cancer) and is implicated in regulating immune cell homeostasis, including regulatory T cells and effector T-cell differentiation.
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