SKU: 42275063082

Biotinylated EGFR His&Avi Tag Protein, Human

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Description

Biotinylated EGFR His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms ERBB, ERBB1, HER1 Accession P00533 1 Amino Acid Sequence Leu25 Ser645, with C terminal His&Avi tag

Product Specification


Species Human
Synonyms ERBB, ERBB1, HER1
Accession P00533-1
Amino Acid Sequence

Leu25-Ser645, with C-terminal His&Avi tag LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSGGGSGGGSHHHHHHHHHHGLNDIFEAQKIEWHE

Expression System HEK293
Molecular Weight 95-110kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Biotin
Tag Avi Tag, His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Fadi S. Saadeh: EGFR as a clinical marker in glioblastomas and other gliomas, The International Journal of Biological Markers 2018, Vol. 33(1) 22 -32.

Background

The Epidermal Growth Factor Receptor (EGFR)is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). EGFR is activated after homodimerization or heterodimerization. Heterodimerization is an important mechanism that allows the activation of all EGFR in response to ligand stimulation. The activated EGFR binds to many signaling proteins and stimulates the activation of many signaling pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the EGFR.EGFR is overexpressed or mutated in many cancers, especially in breast cancer, ovarian cancer, and non-small cell lung cancer. The overexpression and overactivation of EGFR is correlated with poor prognosis, drug resistance, cancer metastasis, and lower survival rate.

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Exchange/Return Notes
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SKU: 42275063082

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amazonfan
Port Orchard, US
★★★★★ 4
I wanted to love these....
Size: 8, Color: Sand
I really wanted to love these, and I *almost* did. They are comfortable and cute. But they are a little wide across the mid-foot so they were a little sloppy on my feet. The platform is quite high, and while at 5'3" I appreciated the extra height, between that and being too wide, I felt they were an accident waiting to happen. If they were slightly more narrow and a little lower, I would have been in love, but I had to return them. They seem true to size except for the extra width.
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Reviewed in the United States on March 10, 2026
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Mur
Boise, US
★★★★★ 5
Comfort in a Slide
Size: 7.5, Color: Black
These are true to size and extremely comfortable. I prefer the extra height that they provide and the quality is 10/10. I would purchase in another color and highly recommend them if you’re looking for these attributes in a slide.
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Reviewed in the United States on April 25, 2026
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Melissa Lynne
New York, US
★★★★★ 5
Gorgeous shoes, worth the price, totally comfortable!
Size: 8, Color: Black
These are so comfortable! They fit perfect, the suede is really soft and the foot bed has a lot of cushion. They fit very true to size, I got a size 8,
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Reviewed in the United States on April 4, 2026
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Karey Gray
Chelsea, US
★★★★★ 5
Terrific sandal for comfort and adding height!
Size: 7, Color: Dark Chestnut
Very comfortable. I have trouble with heel pain and these sandals are terrific! They are well made - good quality. The brown color is exactly as shown. I would recommend.
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Reviewed in the United States on June 8, 2026
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Vanessa Maciel
Charlottesville, US
★★★★★ 5
great product
Size: 8, Color: Black
love cute and comfy
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Reviewed in the United States on May 12, 2026

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