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Description
Biotinylated LAIR2/CD306 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LAIR2, CD306 Accession Q6ISS4 Amino Acid Sequence Gln22 Pro152, with C terminal 8*His&Avi tag QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAPIEGRMDHHHHHHHHGLNDIFEAQKIEWHE Expression System HEK293 Molecular Weight 20 25kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance
Product Specification
| Species | Human |
| Synonyms | LAIR2, CD306 |
| Accession | Q6ISS4 |
| Amino Acid Sequence | Gln22-Pro152, with C-terminal 8*His&Avi tag QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAPIEGRMDHHHHHHHHGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 20-25kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Lebbink R J. et al. (2008) The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction. J Immunol. 180(3): 1662-1669. |
Background
The leukocyte-associated Ig-like receptor-2 (CD306) is an ITIM-containing inhibitory immune receptor, belonging to the Ig superfamily. LAIR-2 is encoded by a gene located in the vicinity of the LAIR-1 gene in the leukocyte receptor complex on human chromosome 19q13.4. The predicted LAIR-2 protein has a single Ig-like domain sharing 84% sequence homology with hLAIR-1, and the molecule lacks a transmembrane and cytoplasmic region suggesting it is a secreted protein. In contrast to hLAIR-1, LAIR-2 has no orthologs in mice or rats. The membrane ligand for LAIR-1 and LAIR-2 was expressed extensively and ligand recognition was of cross-species. LAIR-2 blocked the interaction of LAIR-1 with its ligand but LAIR-1 didn't block the interaction of LAIR-2 with its ligand. LAIR-2 had a higher affinity for collagen than did LAIR-1. LAIR-2 is a more potent antagonist of LAIR-1 function in vivo, while both sLAIR-1 and LAIR-2 are potential biomarkers. Recently shown that recombinant LAIR-2–His is able to interfere with collagen-induced platelet aggregation and that it efficiently inhibits the binding of collagen to glycoprotein VI and von Willebrand factor.
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4.8 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 5
Great value and cute toy!
Style: Squeaky Duck
Our dog LOVES this toy. Once he chewed through the duck the inside toy became one of his favorites.
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Reviewed in the United States on February 4, 2026
★★★★★ 2
Destructable
Style: Squeaky Duck
Destructible!!!! My 13-pound dog stripped the bird toy down in a day. I’d recommend strong or highly motivated chewers get a different toy.
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Reviewed in the United States on March 28, 2026
★★★★★ 5
Great for puppies
Size: Small(3/8"-6ft), Color: Pink
Perfect for a new puppy. It’s thick and sturdy so the pup can’t chew through it easily. The slip knot slides well so the pup is secured but not choked. Easy to hold. Great product.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Functional and pretty leash!
Size: Large(1/2"-6ft), Color: Grey
This is a convenient leash for taking pup out for a quick potty break. Obviously, the dog doesn't care about the aesthetic but I sure do, and this thing is cute. The leather accents are lovely and the whole thing seems to be high quality for a good price. For a dog that doesn't pull on the leash, this thing is great and super easy to use. Our dog is still learning not to pull, so this wouldn't be suitable for a long walk just yet.
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Reviewed in the United States on April 23, 2026
★★★★★ 5
Great Slip-On Leash
Size: Large(1/2"-6ft), Color: Black
Great little leash. I originally bought this for the neighborhood pitbull that keeps escaping. First time I was able to get him by the collar and walk him home hunched over, but the second time he escaped he had slipped it, so I had to carry him home. i figured it was time to get a leash to have one on hand (we didn't have our own dog at the time). This was the first slip over leash I spotted on here and so I grabbed it just to have here the next time he shows up. Really glad I did. If I approach friendly, he comes over tail wagging looking for affection. I can easily slip it over as I give him some pets and then he happily walks home with me. It works perfectly for that.
Then comes our recently adopted puppy. She came with a very small collar (but she's already 22 lbs) and the clip on leash we got for her was kind of cumbersome to put on with that tiny little D-ring, so this ended up becoming our go-to leash for walks as well. Much easier to take on and off, and especially easy to slip over for those times I let her run off leash and she's not cooperating with it going back on. Very strong without being too heavy, and easy on both my hands and the dog's neck. I'll probably go back to a clip-on once she fits into her larger/wider collar (which will be much more comfortable for her), but for now this is a fantastic temporary solution. I cannot recommend it enough.
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Reviewed in the United States on March 30, 2026