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Description
S-RMab® CD23 Recombinant Rabbit mAb (SDT-028-67)Product Specification Host Rabbit Antigen CD23 Synonyms BLAST 2; C type lectin domain family 4 member J; Fc epsilon RII; Immunoglobulin E binding factor; Lymphocyte IgE receptor; FCER2; CD23A; CLEC4J; FCE2; IGEBF Location Cell membrane Accession P06734 Clone Number SDT 028 67 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | CD23 |
| Synonyms | BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; FCER2; CD23A; CLEC4J; FCE2; IGEBF |
| Location | Cell membrane |
| Accession | P06734 |
| Clone Number | SDT-028-67 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:2000 | |
| IF | 1:200 |
Background
CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. CD23 is known to have a role of transportation in antibody feedback regulation. Antigens which enter the blood stream can be captured by antigen specific IgE antibodies. The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell lymphoma (CD23-negative). CD23 can also be demonstrated in germinal centre follicular dendritic cells using immunohistochemistry but is minimally expressed by benign germinal center B cells.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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