SKU: 44285692766

Haptoglobin Recombinant Rabbit mAb (SDT-339-45)

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Description

Haptoglobin Recombinant Rabbit mAb (SDT-339-45)Product Specification Host Rabbit Antigen Haptoglobin Immunogen Recombinant Protein Accession P00738 Clone Number SDT 339 45 Antibody Type Rabbit mAb Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize Hemoglobin Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rabbit
Antigen Haptoglobin
Immunogen Recombinant Protein
Accession P00738
Clone Number SDT-339-45
Antibody Type Rabbit mAb
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize Hemoglobin
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds with high affinity to free hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. Haptoglobin, in its simplest form, consists of two alpha and two beta chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Hp exists in two allelic forms in the human population, so-called Hp1 and Hp2, the latter one having arisen due to the partial duplication of Hp1 gene. Three genotypes of Hp, therefore, are found in humans: Hp1-1, Hp2-1, and Hp2-2. Hp of different genotypes have been shown to bind hemoglobin with different affinities, with Hp2-2 being the weakest binder. Hemoglobin that has been released into the blood plasma by damaged red blood cells has harmful effects. The HP gene encodes a preproprotein that is processed to yield both alpha and beta chains, which subsequently combines as a tetramer to produce haptoglobin. Haptoglobin functions to bind the free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical consequences. Haptoglobin polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases, including infections, atherosclerosis, and autoimmune disorders. These effects are explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis. Recent evidence is growing that haptoglobin is involved in the immune response as well. The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology.

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SKU: 44285692766

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E
Verified Purchase
Ellie
Battle Creek, US
★★★★★ 5
Great for agressiver chewers
Color: Grilled color
Very resistant
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 1, 2026
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Lgiff
Natrona Heights, US
★★★★★ 5
This has been a challenge for my extreme chewer! The toy is winning
Color: Green
Indestructible? Not for my pitbull. Except on this toy. She has slowly chewed some of the outer portion on the backside, but it still has a lot of gnawing time left. This is her go-to toy now. she carries it nearly everywhere. She loves it. I am amazed at how well it is holding up. Within minutes, hours or a few days, the other "indestructible" toys I've purchased, never survived as described. This is a heavy toy! Not for the weak! I cannot stress enough the extreme chewer my dog is. Yet, I can see this toy lasting months. It won't be pretty then but it will most likely still be a favorite chew toy. I'm glad I found this and will be buying more. FYI's... 1) Chewability-5 stars 2) Softness-1 star, it's solid but chewable, 3) Bounce-0 stars, No bounce, it's heavy!, Playability- 5 stars. My dog plays with it, lets it lay with her when resting. Nearly always within her reach. She sleeps with it! That's love.
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Reviewed in the United States on January 2, 2026
M
Verified Purchase
Michele Johnson
Louisville, US
★★★★★ 5
My buddy has been chewing on this for an hour!
Color: Green, Color: Green
This dog toy has been a great addition to our dog’s toy collection! My dog can be a pretty aggressive chewer, so I’m always looking for toys that are durable and can actually hold up to daily play. This one has been surprisingly tough and has lasted much longer than many other toys we’ve tried. The material feels strong and well made, and the design makes it easy for my dog to grip and chew. He loves carrying it around and tossing it during playtime. It’s also great for keeping him busy and helping reduce boredom, especially when he has extra energy to burn. Another thing I like is the texture of the toy. It seems to help keep my dog engaged, and it’s sturdy enough that I don’t worry about it falling apart right away like some softer toys do. It’s been used for chewing, tugging, and even some fetch around the house, and it’s still holding up really well. The only small drawback is that I wish it had a squeaker inside. My dog absolutely loves squeaky toys, and I think that would make it even more exciting and keep him interested for longer periods of time. Overall though, this is a very solid and durable dog toy that’s perfect for dogs that love to chew. If you’re looking for something tough that can help keep your dog entertained and reduce boredom, this is definitely worth try
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Reviewed in the United States on March 12, 2026
E
Verified Purchase
Elizabeth Funderburg
New York, US
★★★★★ 5
Great Toy For Aggressive Chewers
Color: Green, Color: Green
My Boy loves it! It is a little heavy but it keeps him busy. Very strong and sturdy for aggressive chewing. We named it Ally the Alligator. He loves it definitely would recommend!
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Reviewed in the United States on May 25, 2026
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Larry
Phoenix, US
★★★★★ 4
Quality material and looks good.
Color: Green
Great chew toy for medium to large dogs. Seems to hold up to their chewing. Very heavy and could damage floors or furniture if your dog happens to throw it in the air.
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Reviewed in the United States on April 10, 2026

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