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Description
UBR2 Recombinant Rabbit mAb (S-2041-163)Product Specification Host Rabbit Antigen UBR2 Synonyms E3 ubiquitin protein ligase UBR2; N recognin 2; Ubiquitin protein ligase E3 alpha 2; Ubiquitin protein ligase E3 alpha II; C6orf133; KIAA0349; UBR2 Immunogen Synthetic Peptide Location Nucleus Accession Q8IWV8 Clone Number S 2041 163 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample 293T, Jurkat, BxPC 3, HeLa, NIH 3T3, mouse liver, C6, COS 7
Product Specification
| Host | Rabbit |
| Antigen | UBR2 |
| Synonyms | E3 ubiquitin-protein ligase UBR2; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II; C6orf133; KIAA0349; UBR2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q8IWV8 |
| Clone Number | S-2041-163 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | 293T, Jurkat, BxPC-3, HeLa, NIH/3T3, mouse liver, C6, COS-7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| ICC | 1:100 | Hu |
Background
UBR2 is an evolutionarily conserved E3 ubiquitin ligase of the N-end rule pathway that selectively recognizes and ubiquitinates proteins bearing specific N-terminal destabilizing residues, thereby targeting them for proteasomal degradation; it contains an N-terminal UBR box that binds type-1 (basic) and type-2 (bulky hydrophobic) N-degrons, a central RING finger domain that coordinates ubiquitin-charged E2 enzymes, multiple auto-inhibitory and substrate-recognition motifs, and C-terminal regions that mediate interactions with transcription factors, chromatin remodelers, and DNA damage response proteins, enabling UBR2 to regulate diverse processes such as spermatogenesis, neurogenesis, cardiac development, genomic stability, and metabolic homeostasis through both proteolytic and non-proteolytic ubiquitylation events.
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