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Description
IFITM3 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen IFITM3 Synonyms Interferon induced transmembrane protein 3; Dispanin subfamily A member 2b (DSPA2b); Interferon inducible protein 1 8U Immunogen Synthetic Peptide Location Cytoplasm, Lysosome, Endosome, Cell membrane Accession Q01628 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa, HepG2, THP 1 Purification Immunogen Affinity Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | IFITM3 |
| Synonyms | Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b (DSPA2b); Interferon-inducible protein 1-8U |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Lysosome, Endosome, Cell membrane |
| Accession | Q01628 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa, HepG2, THP-1 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
Background
Interferon-induced transmembrane protein 3 (IFITM3) is a small transmembrane protein that plays a crucial role in various cellular functions. It is ubiquitously expressed in most cell types, primarily localized in endosomal and lysosomal membranes, and can also be found in plasma and endoplasmic reticulum membranes. IFITM3 is best known for its antiviral activity, as it can inhibit the entry of a broad spectrum of viruses, including influenza A virus, Zika virus, coronaviruses, and others, by preventing viral membrane fusion with host cells. In addition to its antiviral function, IFITM3 is involved in cell adhesion, stem cell migration, and immune regulation. It has also been implicated in tumor development and progression, as well as in the pathogenesis of diseases like Alzheimer's Disease. The expression of IFITM3 is regulated by interferons, and genetic variations in the IFITM3 gene have been associated with susceptibility to viral infections.
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