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Description
Envelope Glycoprotein D (gD) His Tag Protein, HSV-2 (strain 333)Product Specification Synonyms Glycoprotein D, gD Accession P03172 1 Amino Acid Sequence Lys26 Thr310 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 40 50kDa (Reducing) Purity 95% by SDS PAGE,> 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Synonyms | Glycoprotein D, gD |
| Accession | P03172-1 |
| Amino Acid Sequence | Lys26-Thr310 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 40-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE,> 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Cairns TM, Atanasiu D, Saw WT, Lou H, Whitbeck JC, Ditto NT, Bruun B, Browne H, Bennett L, Wu C, Krummenacher C, Brooks BD, Eisenberg RJ, Cohen GH. Localization of the Interaction Site of Herpes Simplex Virus Glycoprotein D (gD) on the Membrane Fusion Regulator, gH/gL. J Virol. 2020 Sep 29;94(20):e00983-20. |
Background
HSV-2 (strain 333) Envelope Glycoprotein D (gD) His Tag Protein is a critical envelope glycoprotein on the surface of herpes simplex virus type 2, recombinantly expressed with a His-tag for convenient purification and detection. Structurally, gD is a type I transmembrane glycoprotein comprising an N-terminal immunoglobulin-like fold domain, a flexible hinge region, and a C-terminal hydrophobic anchor; the His-tag is typically fused at the C-terminus to preserve N-terminal receptor-binding activity. Functionally, gD serves as the "molecular key" for viral entry, specifically recognizing and binding host cell surface receptors (HVEM, nectin-1, or 3-OS HS) to trigger the gB/gH-gL-mediated membrane fusion cascade, while also representing the primary target for neutralizing antibodies. Clinically, it holds significant importance: as a specific antigen for HSV-2 infection diagnosis supporting serological testing; as the core candidate molecule for subunit vaccines, exemplified by GSK's Herpevac vaccine developed based on gD; and its epitope mapping provides structural foundations for therapeutic monoclonal antibodies and entry inhibitor design, carrying substantial translational value for controlling genital herpes and neonatal herpes infections.
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