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Description
CD99 Mouse mAb (S-2121-45)Product Specification Host Mouse Antigen CD99 Synonyms CD99 antigen; 12E7; E2 antigen; Protein MIC2; T cell surface glycoprotein E2; MIC2; MIC2X; MIC2Y Immunogen Recombinant Protein Location Membrane Accession P14209 Clone Number S 2121 45 Antibody Type Mouse mAb Isotype IgM Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample U 937, Jurkat, Molt 4, HuT 78, HUVEC, THP 1, SH SY5Y, mouse spleen, rat spleen, rat thymus Concentration 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD99 |
| Synonyms | CD99 antigen; 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; MIC2; MIC2X; MIC2Y |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P14209 |
| Clone Number | S-2121-45 |
| Antibody Type | Mouse mAb |
| Isotype | IgM |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | U-937, Jurkat, Molt-4, HuT-78, HUVEC, THP-1, SH-SY5Y, mouse spleen, rat spleen, rat thymus |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
CD99, also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein encoded by the CD99 gene. It is widely expressed in various cell types, including hematopoietic cells, endothelial cells, and many types of cancer cells. This protein plays crucial roles in multiple biological processes such as cell adhesion, migration, differentiation, and apoptosis. In the immune system, CD99 is involved in T-cell activation, maturation, and the regulation of leukocyte transmigration. It also has a significant impact on tumor biology, as it is often overexpressed in cancers like Ewing sarcoma and certain leukemias. Engagement of CD99 by specific antibodies can induce caspase-independent cell death in tumor cells, making it a potential therapeutic target.
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Exchange/Return Notes
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