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Description
Human TGF-β1 Protein, His TagProduct Specification Species Human Synonyms Transforming growth factor beta 1 proprotein, TGFB1, TGFB Accession P01137 Amino Acid Sequence Protein sequence (P01137, Met1 Ser390, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Transforming growth factor beta-1 proprotein, TGFB1, TGFB |
| Accession | P01137 |
| Amino Acid Sequence | Protein sequence (P01137, Met1-Ser390, with C-His Tag) MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 46.5 kDa Observed MW: 15, 40, 55 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
TGFB1 (Transforming Growth Factor Beta 1) is a multifunctional cytokine belonging to the TGF-β superfamily, playing crucial roles in cell proliferation, differentiation, apoptosis, and immune regulation. It is secreted by various cell types, including immune cells, and functions in both autocrine and paracrine signaling. TGFB1 is pivotal in wound healing, fibrosis, and maintaining tissue homeostasis, but its dysregulation is linked to cancer, autoimmune diseases, and fibrotic disorders. It signals through SMAD-dependent and non-SMAD pathways, modulating gene expression.
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