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Description
Phospho-Akt (Ser473) Recombinant Rabbit mAb (S-622-64)Product Specification Host Rabbit Antigen Phospho Akt (Ser473) Synonyms RAC alpha serine threonine protein kinase, Protein kinase B (PKB), Protein kinase B alpha (PKB alpha), Proto oncogene c Akt, RAC PK alpha, PKB, RAC, AKT1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession P31749 Clone Number S 622 64 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM, IP Reactivity Hu Predicted Reactivity Rt, Ms
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Akt (Ser473) |
| Synonyms | RAC-alpha serine/threonine-protein kinase, Protein kinase B (PKB), Protein kinase B alpha (PKB alpha), Proto-oncogene c-Akt, RAC-PK-alpha, PKB, RAC, AKT1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P31749 |
| Clone Number | S-622-64 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM, IP |
| Reactivity | Hu |
| Predicted Reactivity | Rt, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:500 | |
| ICFCM | 1:500 | |
| Dot Blot | 1:1000 | |
| IP | 1:50 |
Background
Akt or Protein kinase B, is a serine/threonine kinase that plays an important role in regulating a number of cellular processes such as growth, metabolism and survival. The importance of the Akt pathway is highlighted by the mutation of various components of the pathway in human cancers such as the PTEN and PI3-kinase (P110α), which occur in more than 30% of human tumors. For Akt to achieve full activation, phosphorylation is needed at both serine 473 (ser473) of the hydrophobic tail and threonine 308 (thr308) of the activation motif, upon growth factor ligation to the receptor tyrosine kinases.
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