Cytokeratin 1 Recombinant Rabbit mAb (SDT-3225-22)

Cytokeratin 1 (CK1), encoded by the KRT1 gene, is a type II cytokeratin that heterodimerizes with cytokeratin 10 (CK10) to form intermediate filaments specifically expressed in the suprabasal layers of stratified squamous epithelia, including skin, oral mucosa, and esophagus. This 67-kDa protein plays a critical structural role in maintaining mechanical integrity of keratinocytes and protecting epithelial tissues from mechanical stress, osmotic shock, and apoptosis. CK1 contains a central α-helical rod domain flanked by non-helical head and tail domains, with the tail domain undergoing extensive post-translational modifications including phosphorylation and glycation that regulate filament assembly and keratinocyte differentiation. Mutations in KRT1 cause epidermolytic hyperkeratosis (EHK), a severe autosomal dominant ichthyosis characterized by epidermal blistering and hyperkeratosis due to keratin filament collapse and keratinocyte fragility. Beyond its structural functions, CK1 participates in cell signaling, wound healing, and stress response pathways, and serves as an important histopathological marker for distinguishing epithelial-derived carcinomas from mesenchymal tumors. The protein's expression pattern makes it clinically valuable for identifying squamous cell carcinomas and stratified epithelial origins in diagnostic pathology.