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Description
IL-13 Protein, HumanProduct Specification Species Human Synonyms Interleukin 13, IL 13 Accession P35225 Amino Acid Sequence Gly35 Asn146 Expression System E. coli Molecular Weight 10 12 kDa (Reducing) Purity >95% by SDS PAGE. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 4mM HCl Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in Reconstitute Buffer after rapid centrifugation. Stability &
Product Specification
| Species | Human |
| Synonyms | Interleukin-13, IL-13 |
| Accession | P35225 |
| Amino Acid Sequence | Gly35-Asn146 |
| Expression System | E.coli |
| Molecular Weight | 10-12 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 4mM HCl |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in Reconstitute Buffer after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Cell. 2008 Jan 25;132(2):259-72. |
Background
Interleukin-13 (IL-13) is a pleiotropic type 2 cytokine discovered in 1993 as a product of activated T helper 2 (Th2) cells, crucial for orchestrating allergic inflammation and immune responses. Signals through a heterodimeric receptor complex comprising IL-13Rα1 and IL-4Rα (type II IL-4 receptor). IL-13 binds IL-13Rα1 with moderate affinity (KD = 30 nM), recruiting IL-4Rα to activate downstream pathways. Activation of JAK1 and JAK2/TYK2 tyrosine kinases, leading to STAT6 phosphorylation, dimerization, and nuclear translocation to regulate gene transcription.
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