SKU: 48937012242

PDGFR alpha Recombinant Rabbit mAb,PBS Only (SDT-3353)

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Description

PDGFR alpha Recombinant Rabbit mAb,PBS Only (SDT-3353)Product Specification Host Rabbit Antigen PDGFR alpha Synonyms Platelet derived growth factor receptor alpha; PDGF R alpha; PDGFR alpha; Alpha platelet derived growth factor receptor; Alpha type platelet derived growth factor receptor; CD140 antigen like family member A; CD140a antigen; Platelet derived growth factor alpha receptor; Platelet derived growth factor receptor 2 (PDGFR 2); CD140a; PDGFR2; RHEPDGFRA; PDGFRA Location Cell membrane Accession

Product Specification


Host Rabbit
Antigen PDGFR alpha
Synonyms Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2 (PDGFR-2); CD140a; PDGFR2; RHEPDGFRA; PDGFRA
Location Cell membrane
Accession P16234
Clone Number SDT-3353
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample A204, SH-SY5Y, NIH/3T3, mouse lung, rat brain, rat heart, rat lung
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS
Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:500-1:1000 Hu, Ms, Rt
IHC-P 1:500 Hu, Ms, Rt
ICC 1:500 Hu

Background

PDGFR alpha, CD140a (also called platelet-derived growth factor receptor-alpha, PDGFR-α) is a 170-kDa glycosylated cell-surface receptor tyrosine kinase encoded by the PDGFRA gene, featuring an extracellular ligand-binding region with five immunoglobulin-like domains, a single transmembrane segment and an intracellular split tyrosine-kinase domain; upon binding PDGF-AA, -AB or -BB it forms homo- or heterodimers, triggers downstream signalling cascades that drive proliferation, migration and differentiation of mesenchymal and glial cells, and is indispensable for embryogenesis of kidney, testis and other organs, wound healing and maintenance of hematologic tissues, while PDGFRA mutations or amplifications are linked to clonal hypereosinophilic neoplasms, gastrointestinal stromal tumours, gliomas and hepatocellular carcinoma, making CD140a a potential therapeutic target in these cancers .

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SKU: 48937012242

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4.3 ★★★★★
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Verified Purchase
Dr. Earl C. Johnson
Massapequa, US
★★★★★ 4
Enjoyed reading some of the best poems ever written. Took me places I’ve never been.
Format: Paperback
Some of the poems were difficult to comprehend and may require a re-reading to understand their full meaning. But that is the brilliance of G. Brooks, putting you in places of the mind that one has never been. Won’t recommend for newbies!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 10, 2021
K
Verified Purchase
Kymberlyn A Reed (The Fountain Pen Diva)
Charlottesville, US
★★★★★ 4
A Great Historical Noir
Format: Kindle
As a lifelong Angeleno, the dark history of the city is often glossed over. Much like Chavez Ravine, the history of Union Station is one of violence and the forced displacement of the original Chinatown and its residents. It's in this setting where the mysterious death of Chinese actress Lulu Wong (who is somewhat based on the real life of actress Anna Mae Wong) begins, and took me into the lives of the amazing Chow sisters - May and Gemma - both of whom have their own reasons for wanting justice. They know the LA cops won't bother to solve the death of a Chinese woman, no matter how famous. It's also a matter of saving their beloved Chinatown from being destroyed in order to build Union Station. I absolutely loved how immersive this story felt and how authentic all of the characters were.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 17, 2024
S
Verified Purchase
Sandy Worchester
Pawtucket, US
★★★★★ 5
noir
Format: Kindle
Always the last person you can think of is the murderer. The same with this book also. I love learning about new cultures and you can learn some things about Chinese culture from this book. So interesting
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 6, 2024
H
Heather Harrington
Draper, US
★★★★★ 3
Pretty good
Format: Hardcover
In 1932, Lulu Wong made a name for herself by leaving Chinatown and becoming a Hollywood star. Most girls who look like her don't get lead roles, so Lulu is the pride of her neighborhood. So everyone is shocked when Lulu's body is found in a local stable far from her Beverly Hills home by her friends, sisters May and Gemma. The girls know that the police won't look too hard into the murder, so they decide to take matters into their own hands. As they investigate, the sisters discover a plot to frame Chinatown as a den of iniquity that should be demolished in favor of constructing a new train station. May and Gemma soon find themselves in a race against time to not only find justice for their friend but save their neighborhood, all while being targeted by a killer. I've only read a few books by Lee, but they've all been winners. I love her style when it comes to YA historical fiction. She crafts compelling plotlines that include real issues of the time with characters you can't help but root for. I liked both our main characters. May was more logical and reserved, while Gemma was a spitfire, but they balanced each other perfectly. I liked how we got both of their POVs, but I did enjoy Gemma's slightly more because I loved her gumption. I thought the mystery was well-paced and kept me intrigued. I had no clue how it would play out, and I liked how Lee wrapped it all up. It did drag a bit in the middle, but overall, I thought it was entertaining.
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Reviewed in the United States on April 23, 2024
J
Verified Purchase
J. Kuntze
West Palm Beach, US
★★★★★ 4
not as good but nearly there
Format: Kindle
I had hoped that Kill Her Twice would grab my attention in the first few pages and not let go till the very end (like her other books I have read), but this one had a very. Slow. Start. The mystery of the death of a young Chinese starlet in California in the early 1900’s is the catalyst that starts everything: new characters are continuously introduced, their motivations becoming clear and murky and clear again several times before the last quarter of the book. But. The last quarter (finally) had me hooked.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 1, 2025

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