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Description
CD56 Recombinant Rabbit mAb ,PBS Only(SDT-2427-1)Product Specification Antigen CD56 Synonyms Neural cell adhesion molecule 1; N CAM 1; NCAM 1; NCAM; NCAM1 Immunogen Recombinant Protein Location Cell membrane Accession P13591 Clone Number SDT 2427 1 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample NK 92, SH SY5Y Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12
Product Specification
| Antigen | CD56 |
| Synonyms | Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; NCAM; NCAM1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P13591 |
| Clone Number | SDT-2427-1 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | NK-92, SH-SY5Y |
| Purification | Protein A |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
| ICC | 1:500 | Hu |
Background
Neural cell adhesion molecule 1 (NCAM-1), also known as CD56, is a cell adhesion protein belonging to the immunoglobulin superfamily. It is expressed on various cell types including neurons, muscle cells, and immune cells like natural killer (NK) cells. NCAM-1/CD56 plays crucial roles in cell-to-cell and cell-matrix interactions during development and differentiation, regulating processes such as neurogenesis, neurite outgrowth, axonal guidance, and cell migration in the nervous system. In the immune system, it is involved in the expansion of T lymphocytes, B lymphocytes, and NK cells. NCAM-1/CD56 also triggers signaling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). Additionally, it serves as a biomarker for certain diseases, such as malignant tumors in the nervous system and neuroendocrine carcinoma.
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Exchange/Return Notes
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