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Description
Mouse Anti-Human CD124 Antibody (S-3171)Product Specification Host Mouse Antigen CD124 Synonyms Interleukin 4 receptor subunit alpha; IL 4 receptor subunit alpha; IL 4R subunit alpha; IL 4R alpha; IL 4RA; IL4RA; IL4R Location Secreted, Cell membrane Accession P24394 Clone Number S 3171 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood Leukocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Mouse |
| Antigen | CD124 |
| Synonyms | Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4RA; IL4R |
| Location | Secreted, Cell membrane |
| Accession | P24394 |
| Clone Number | S-3171 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD124, also known as interleukin-4 receptor alpha (IL-4Rα), is a ~140 kDa type I transmembrane glycoprotein of the class I cytokine receptor family that serves as the ligand-binding subunit for both interleukin-4 and interleukin-13: upon IL-4 ligation it pairs with the common γ-chain (CD132) to form the type I IL-4 receptor on hematopoietic cells or with IL-13Rα1 to form the type II receptor on non-hematopoietic cells, thereby activating JAK1/3–STAT6 signaling that drives Th2-cell differentiation, B-cell IgE class switching, alternative macrophage activation, mucus production and allergic inflammation, while a soluble ectodomain generated by alternative splicing or metalloprotease shedding retains ligand-binding capacity and functions as a decoy receptor that inhibits IL-4-mediated T-cell proliferation and IL-5 up-regulation; genetic polymorphisms and dysregulated expression of CD124 have been linked to atopy, asthma, HIV-1 resistance and tumor progression, making it a prominent therapeutic target in type 2-biased inflammatory diseases.
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