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Description
LMP2A Recombinant Rabbit mAb (S-2247-41)Product Specification Host Rabbit Antigen LMP2A Synonyms Latent membrane protein 2; Terminal protein; LMP2 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P13285 1 Clone Number S 2247 41 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity EBV Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | LMP2A |
| Synonyms | Latent membrane protein 2; Terminal protein; LMP2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P13285-1 |
| Clone Number | S-2247-41 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | EBV |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 |
Background
Latent Membrane Protein 2A (LMP2A) is a viral protein encoded by the Epstein-Barr virus (EBV) and is expressed during the latent phase of EBV infection in B cells. It is a transmembrane protein with three distinct domains: an N-terminal cytoplasmic domain containing ITAM motifs that mimic B-cell receptor (BCR) signaling, a transmembrane domain with 12 segments, and a C-terminal domain that mediates protein dimerization. LMP2A plays a crucial role in maintaining viral latency by blocking BCR signal transduction, thereby preventing B-cell activation and apoptosis. Additionally, it has been implicated in promoting B-cell survival and proliferation through pathways such as the mTOR pathway and by modulating cellular metabolism. LMP2A is consistently expressed in various EBV-associated malignancies, including Burkitt's lymphoma, Hodgkin's lymphoma, and nasopharyngeal carcinoma, highlighting its significance in viral oncogenesis.
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