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Description
PE-Cy7 Armenian hamster Anti-Human/mouse/rat CD278 Antibody (S-R578)Product Specification Host Armenian hamster Antigen CD278 Synonyms Inducible T cell costimulator; Activation inducible lymphocyte immunomediatory molecule; AILIM; ICOS Location Cell membrane Accession Q9Y6W8 Clone Number S R578 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu, Ms, Rt Purification Protein G Concentration 0. 2 mg ml Conjugation PE Cy7 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Armenian hamster |
| Antigen | CD278 |
| Synonyms | Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; AILIM; ICOS |
| Location | Cell membrane |
| Accession | Q9Y6W8 |
| Clone Number | S-R578 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD278, also known as ICOS (Inducible T-cell Costimulator), is a type I transmembrane glycoprotein that belongs to the CD28 family of costimulatory immunoreceptors. It is expressed on the surface of activated T cells, including cytotoxic T cells, regulatory T cells (Tregs), and other types of T cells. Its ligand, ICOSL (B7-H2 or CD275), is found on antigen-presenting cells (APCs) such as dendritic cells and macrophages, as well as on B cells. ICOS functions as a homodimer and plays a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. The interaction between ICOS and ICOSL enhances T-cell activation, proliferation, and differentiation, and is essential for the development of follicular helper T cells (Tfh) and efficient B-cell antibody responses. ICOS has also been implicated in various disorders, including immunodeficiency and autoimmune diseases. In cancer immunotherapy, ICOS expression has been identified as a potential predictive biomarker for responses to checkpoint inhibitor treatments.
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4.1 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
Takes a beating - looks like new!
Color: Blue/Medium, Size: Blue
EDITED AGAIN, 12/28/22:
My boy still has his original blue one of these and the yellow one from way back. He's received a couple more over the years which he's managed to sneak out of the house and lose - evidently neighbor dogs or perhaps foxes, etc love them, too, and carry them off?! At any rate, he'd managed to get himself back to his original two, so I bought him a late Christmas present of a new yellow bone. He just opened the package (with help, of course - he's smart, but lacks the necessary opposing thumbs to do it on his own) and he was ecstatic! He reached into the mailing envelope, grabbed it, gave it a couple of triumphant tosses then ran for his bed, pulled a blanket in, and has been chewing, fighting with, burying in the blanket and "discovering" it for about a half hour now! I don't know what the attraction is, but he still loves these things and they're still lasting! The only other toys that have lasted more than a day are Nylabones (because he won't even look at them, let alone touch them) and a set of interlocked skinny rubber rings that he's not at all interested in, but if I ask about them, he'll move them around the room for a couple of days to make me feel better! LOL
EDITED TO ADD 2022:
Here I am, back 5 1/2 years later to say my dog STILL has this bone and makes use of it a couple of times a week. And he still loves it and sleeps with it. He has gone through a couple of the smaller version (yellow instead of blue) over this time frame because those get constant use. But that’s amazing in itself!! These are still the only toy I would call indestructible.
Great toy! I have a dachshund who destroys toys in record time. I can hear the amused chuckles now, but anyone who has seen him in action (including rottie, pit bull and Doberman owners) is in awe. He is very methodical and relentless - the mad genius of dog toy torture! Small and quiet but utterly ruthless.
Anyway...my boy has been working on this since the beginning of October and the thing looks like new! I think you can see one tooth mark, otherwise it looks untouched! This is a dog who can reduce Kongs and other rubber toys to a pile of chunks in minutes.
But he also LOVES it - carries it around, brings it into his bed at night to sleep, and when his doxie brother (who is far too dignified to do dog toys) doesn't feel well, it is offered up as a "feel better" snuggly...for about 2 minutes. But it's the thought that counts, right?
I don't know what makes this so attractive to my mini-Jaws and so long-lasting, but it works!
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Reviewed in the United States on February 3, 2017
★★★★★ 5
HEAVEY Duty!
Color: Blue/Medium, Size: Blue
Almost not destructible! My dogs chew through 99% of the toys we purchase, but never this one! The medium size is good for our Doberman with jaws of steel!
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Reviewed in the United States on May 4, 2026
★★★★★ 5
Great chew toy to keep around the house
Color: Blue/Medium, Size: Blue, Color: Blue/Medium, Size: Blue
This came highly recommended by the behavioural team at the animal shelter and it hasn't disappointed. It's interesting reading the reviews, because our power-chewer pit-mix who can get a chunk off a split antler in a matter of minutes, hasn't ever been able to get a bite out of this bone! This is a great play toy for her, because it's soft enough that we can throw it for her to fetch in the house without worrying about breaking/denting something and are able to pull it out of her mouth fairly easily once she brings it back (still hasn't learned "drop it!"). The bone isn't flavored, so she'll rarely go to it on her own to chew on, but we keep it near the couch so if she ever gets bitey, we have it close at hand to offer to her as a chewer. It's also entertaining to tuck it into her collar and have her figure out how to remove it to play with it (see photo for this game and size compared to 50lb mutt).
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Reviewed in the United States on August 15, 2017
★★★★★ 5
Best bouncy bone!
Color: Orange/Large, Size: Orange, Color: Orange/Large, Size: Orange
My pups love these bones! They are soft and rubbery, but very durable. Had them for a little over 6 months and it has survived my extreme chewers and many tug of war games, and only has a few puncture marks! They bounce on my concrete floors and my pup loves to play fetch with this. Great purchase
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Reviewed in the United States on April 27, 2025
★★★★★ 4
Excellent for aggressive chewers
Color: Blue/Medium, Size: Blue
First I would like to say I think Jolly Pets are the best line of dog toys out there if you have an aggressive chewer. Their products have amazed me! And I am not being paid for this review. I have a 155 lb mastiff that is an excellent behaved boy but loves to destroy his toys. I had this bone in large and it held up excellent for about 4-5 months. I ordered it again in medium size by mistake and after 2 weeks it already has pieces missing...my fault. My only complaint is the medium size in blue smells like vanilla perfume. I can't wash it off. Although my handsome boy doesn't seem to mind. I just reordered in large. Also ordered a few other Jolly Pet toys as I am amazed at how they hold up. The "soccer ball" is my dogs favorite. It reinflates itself again and again no matter how much chewing or wear and tear its given. It's just magic!
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Reviewed in the United States on October 1, 2022
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