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Description
PCSK9 His Tag Protein, MouseProduct Specification Species Mouse Synonyms PCSK9, FH3, PC9, FHCL3 Accession Q80W65 Amino Acid Sequence Gln35 Gln694, with C terminal 10* His Tag
Product Specification
| Species | Mouse |
| Synonyms | PCSK9, FH3, PC9, FHCL3 |
| Accession | Q80W65 |
| Amino Acid Sequence | Gln35-Gln694, with C-terminal 10* His Tag QDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 60-68kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Jaén R I. et al. (2022) Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release. Int J Mol Sci. 23(16): 9114. |
Background
PCSK9 (proprotein convertase subtilisin-kexin type 9) is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. PCSK9 undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism.
Atherosclerosis is a cardiovascular disease caused mainly by dyslipidemia and is characterized by the formation of an atheroma plaque and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that induces the degradation of the LDL receptor (LDLR), which contributes to increased levels of LDL cholesterol and the progress of atherosclerosis.
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4.6 ★★★★★
Based on 23 reviews
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Product Reviews
★★★★★ 5
Simple and Elegant
Color: White Gold - 3.5 mm, Ring Size: 8
I was looking for a band that would match my white gold engagement ring. This is it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026
★★★★★ 5
Thick, true fit, comfortable, and perfect!
Color: White Gold - 3.5 mm, Ring Size: 6.4, Color: White Gold - 3.5 mm, Ring Size: 6.4
Excellent price gorgeous comfortable fit, thick and beautiful
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Reviewed in the United States on April 3, 2026
★★★★★ 5
Very much real gold
Color: Yellow Gold - 2 mm, Ring Size: 7, Color: Yellow Gold - 2 mm, Ring Size: 7
At first I thought that it was too tight. I started wearing it for a couple of weeks and it felt great after.
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Reviewed in the United States on May 22, 2026
★★★★★ 5
Buy it
Color: White Gold - 2 mm, Ring Size: 7, Color: White Gold - 2 mm, Ring Size: 7
Beautiful thin band that fits perfectly with my other ring! True to size. Great price for the quality!
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Reviewed in the United States on April 18, 2026
★★★★★ 5
Excellent quality
Color: Yellow Gold - 2 mm, Ring Size: 8
Beautiful ring. It went perfectly with the diamond ring I got her. 10/10 recommend this ring.
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Reviewed in the United States on December 26, 2025
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