Pay in installments of $12.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 1 - Sep 6
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Mouse Anti-Human CD45RA Antibody (S-R377)Product Specification Host Mouse Antigen CD45RA Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; PTPRC Location Cell membrane Accession P08575 Clone Number S R377 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD45RA |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; PTPRC |
| Location | Cell membrane |
| Accession | P08575 |
| Clone Number | S-R377 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD45RA is an isoform of CD45 (leukocyte common antigen), with a molecular weight of approximately 220kDa or 180kDa (the specific value may vary depending on different studies or measurement methods). This protein is primarily expressed on B cells, monocytes, and a small subset of T cells. In T cells, CD45RA plays a crucial role in regulating immune receptor signaling pathways, modulating T cell activation and suppression. In NK cells, CD45RA is essential for the exertion of cytotoxicity. In the thymus, the expression of CD45RA increases as T cells mature, regulating the transition from naive T cells to mature T cells. Additionally, the protein encoded by the CD45RA gene possesses dephosphorylating activity, which can affect the proliferation, differentiation, and activation of immune cells. In medical applications, CD45RA is used in combination with other B-cell antibodies for the study of B-cell lymphomas. It also plays a key role in the diagnosis of diseases such as acute lymphocytic leukemia and aplastic anemia.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy