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Description
PE-Cy7 Mouse Anti-Human CD3ε Antibody (S-R531)Product Specification Host Mouse Antigen CD3 Synonyms T cell surface glycoprotein CD3 epsilon chain; T cell surface antigen T3 Leu 4 epsilon chain; T3E; CD3E Location Cell membrane Accession P07766 Clone Number S R531 Antibody Type Mouse mAb Isotype IgG2a Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation PE Cy7 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD3ε |
| Synonyms | T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; CD3E |
| Location | Cell membrane |
| Accession | P07766 |
| Clone Number | S-R531 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD3ε is a subunit of the CD3 complex, which is a critical component of the T-cell receptor (TCR) complex on T cells. Together with CD3γ, CD3δ, and CD3ζ, it forms the TCR-CD3 complex that plays a vital role in coupling antigen recognition to intracellular signaling pathways. This complex is essential for T cell activation, proliferation, and differentiation. CD3ε contains an extracellular immunoglobulin domain, a transmembrane region, and a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif (ITAM). Upon antigen recognition, the ITAMs in CD3ε are phosphorylated, initiating downstream signaling cascades that lead to T cell activation. Additionally, CD3ε interacts with other signaling molecules like Lck and Nck through its unique motifs, further modulating T cell responses. Its importance in T cell function makes CD3ε a target for immunotherapies, including cancer treatments and autoimmune disease management.
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4.5 ★★★★★
Based on 13 reviews
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Product Reviews
★★★★★ 5
"In a moment of clarity, I realized I knew why a good guy would never be enough..."
Format: Kindle
"...Good guys didn't touch you like the bad guys did. They didn't push the limits. Hold you down. Make you insane with need. Make you scream."
A spin off from the Crows but it's own story. I've been rushing to get to this book (had some others I had to read first). But I could not hold off any longer. I happily picked it up and refused to put it down. This book is going to pick up where we left off with Becca from the Boys of Briar Hall. She has made her way to SoCal Arts and cut off by her dad.
The Kings of Kilburn, also cousins to our Crows, have been asked to watch Becca as a favor. Ava Jade is worried about her. Hardin and Kaleb have their own issues but someone find themselves individually drawn to Becca. And Becca, well her bad guy rep is pulling her to them just as much. What should be toxic, is super HOT.
But the Kings have Saint business as well. Damian St Vincent, the ruthless leader of this Saints chapter, also happens to be the boys father. And they are currently being threatened by a new Irish gang, Sons of Sullivan. This threat is unaliving member of the Saints and messing up relationships that have been established. Damian warns the guys to stay away from Becca because with this threat, it could put her in danger if she is a known associate to the boys. But things are never that easy.
And lastly, we have would could be a third player. Aódhan. He's Irish and has his own secrets. Also super hot and seems to find himself infatuated with Becca too. But the last chapter, we are going to see inside his POV, and there is more to this Irishmen to come for sure.
Cliffhanger! I always want more from Elena Lawson books, but I love them so much I can't wait for the series to be completed before diving in.
**READ YOUR TRIGGER WARNINGS**
Happy Reading Ya'll!
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Reviewed in the United States on April 6, 2023
★★★★★ 3
hoping for a little more
Format: Kindle
I was hoping for a little more with this book as I loved the other series in this “world,” and hoping it’ll come in the 2nd book. During this book I kept skipping pages ahead trying to move things along, just didn’t really feel like much was answered or accomplished but I’m sure that was the authors point in trying to build everything up but for me it just dragged a bit…Will absolutely read book 2 to see how it all unfolds.
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Reviewed in the United States on July 2, 2024
★★★★★ 5
Can’t Wait For The Next Book!!!
Format: Kindle
⭐️⭐️⭐️⭐️⭐️
Review
This is the first book in the new series Kings Of Kilborn University by Elena Lawson and an absolutely fantastic start to the series. This follows after Boys Of Briar Hall Series and we even get to see AJ and the Crows.
This is Becca’s story after she left Thorn Valley and it’s one intense ride to say the least. Trying to avoid the gang violence she previously suffered she gets a fresh start and a chance at independence something she’s been desperate for. When she meets brothers Kaleb and Hardin things get absolutely intense. They are the Kings of Kilborn and also her new tormentors and they become absolutely obsessed with her. This is a story you have absolutely got to read. The chemistry between the three is off the charts even though Becca just wants to keep away from them she can’t deny the connection.
This book will seriously have you on edge, it’s got violence, gang war between the Saints and the O’Sullivan Sons, lots of twists and turns, and unexpected revelations at the end that will leave you needing book two asap. Am seriously looking forward to finding out what happens next for these characters. Definitely an awesome start to new series. Highly recommend this.
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Reviewed in the United States on February 6, 2023
★★★★★ 4
4.5 ⭐ I loved it!
Format: Kindle
Excellent story line.
I have loved all in this book whisch was very smart.
My favorite gentleman here is Aodhan since the begining I fell for him.
The sex chemistry here was amazing!
The only thing I did not like was: they talk about class in the university but we never had a scene in that scenario the rest very good.
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Reviewed in the United States on October 1, 2025
★★★★★ 5
Fun, Smutty, and Just A Little Bloody
Format: Kindle
Thoughts: 💡
This book was exactly what I expected it to be, and I rather liked that. It was twisted and the characters are tormented, more towards the dark end of morally gray. The story eased into the spice, but I would still say that half of the story was smut and some of it was kinky. 😈
I read the series Boys of Briar Hall, so there were some secrets that I already knew and others that I could guess. My enjoyment came from reading about how the characters dealt with their secrets.
Coming into the series I knew that Becca would have an attitude and flaws and I really liked that Lawson stayed true to them. Becca’s development felt like it was earned. This wasn’t a dark novel where a billionaire sweeps in and all the FMCs worldly woes float away. She honestly had to learn to work and balance real issues and build some inner strength.
I don’t know yet if these characters will have the same sort of immortality that was prevalent in Boys of Briar Hall, so far they don’t and I’m hoping it stays that way.
Overall I can’t complain about the mechanics or grammar in the book. There were a few awkwardly stated phrases but I think it’s because they’re colloquially phrases so I let those slide.
We do get three other POVs in the story and I think that both Kaleb and Hardin were well developed. The final POV was a bit of a surprise and I still don’t know what Lawson intends for the character so I’m excited to see what happens in her next book.
Fun Bits:
⚜️ Riches to Rags
⚜️ Dark Secretes
⚜️ Kinky Smut
⚜️ Great Character Development
Spice Scale: 4 🌶️ 🌶️🌶️🌶️/5
Character Dev: 5 💙💙💙💙💙/5
Contemporary Romance: Gang, Enemies to lovers, Dark, RH 📘
POV: Multi 👩❤️👨
CW: Violence, Abuse, DubCon ⚠️
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Reviewed in the United States on May 20, 2023