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Description
Human IL-18 OneStep ELISA KitProduct Specification Antigen IL 18 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 4% Inter assay: 2. 9% Sample type Serum; Plasma; Cell culture supernatant Assay type Sandwich (quantitative) Sensitivity 50. 897 pg mL Range 156. 25 pg mL 10000 pg mL Recovery Serum: 97%, Plasma: 89%,
Product Specification
| Antigen | IL-18 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.4%； Inter-assay: 2.9% |
| Sample type | Serum; Plasma; Cell culture supernatant |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 50.897 pg/mL |
| Range | 156.25 pg/mL – 10000 pg/mL |
| Recovery | Serum: 97%, Plasma: 89%, Cell culture supernatant: 101% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Interleukin-18 (IL-18), a proinflammatory cytokine primarily produced by macrophages, plays a complex role in immune regulation by potently inducing IFN-γ production and, in synergy with IL-12, shifting B-cell responses away from IgE. Its activity is activated by caspase-1 and inhibited by IL-18 binding protein. Paradoxically, IL-18 can also promote IgE production in certain contexts, highlighting its dual function in allergic diseases, while in rheumatoid arthritis, it synergizes with IL-12 and IL-15 to sustain pathogenic Th1 responses and monokine production, underscoring its significance as a therapeutic target.
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Exchange/Return Notes
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