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Description
PAPP-A Recombinant Rabbit mAb (SDT-226-46)Product Specification Host Rabbit Antigen PAPP A Synonyms Pappalysin 1, IGFBP 4ase Immunogen Recombinant Protein Accession Q13219 Clone Number SDT 226 46 Antibody Type Rabbit mAb Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species
Product Specification
| Host | Rabbit |
| Antigen | PAPP-A |
| Synonyms | Pappalysin-1, IGFBP-4ase |
| Immunogen | Recombinant Protein |
| Accession | Q13219 |
| Clone Number | SDT-226-46 |
| Antibody Type | Rabbit mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | null |
Background
PAPP-A is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan.
Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF [PMID: 28035757IF: 8.0 Q1 ].
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