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Description
CD25/IL-2Rα Recombinant Rabbit mAb,PBS Only(SDT-2234-65)Product Specification Host Rabbit Antigen CD25 Synonyms Interleukin 2 receptor subunit alpha; IL 2 receptor subunit alpha; IL 2 RA; IL 2R subunit alpha; IL2 RA; p55; Il2r; Il2ra Immunogen Recombinant Protein Location Membrane Accession P01590 Clone Number SDT 2234 65 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Ms Positive Sample CTLL 2 Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | CD25 |
| Synonyms | Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; p55; Il2r; Il2ra |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P01590 |
| Clone Number | SDT-2234-65 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Ms |
| Positive Sample | CTLL-2 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:100-1:200 | Ms |
| ICC | 1:500 | Ms |
Background
CD25, also known as the interleukin-2 receptor alpha chain (IL2RA), is a type I transmembrane glycoprotein that plays a crucial role in the immune system. It is primarily expressed on the surface of activated T cells and regulatory T cells (Tregs). CD25 is a key component of the high-affinity IL-2 receptor complex, which also includes the IL-2 receptor beta and gamma chains. By itself, CD25 can bind IL-2 with low affinity, but when combined with the beta and gamma chains, it forms a high-affinity receptor that initiates intracellular signaling pathways such as MAPK and JAK/STAT. This receptor complex is essential for the proliferation and activation of T cells, as well as the regulation of immune tolerance by controlling the activity of Tregs. Mutations in the IL2RA gene can lead to deficiencies in IL-2 receptor function, highlighting its importance in maintaining immune homeostasis.
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Exchange/Return Notes
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