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Description
PINK1 Recombinant Rabbit mAb (S-3135-28)Product Specification Host Rabbit Antigen PINK1 Synonyms Serine threonine protein kinase PINK1, mitochondrial; BRPK; PTEN induced putative kinase protein 1 Immunogen Synthetic Peptide Location Cytoplasm, Mitochondrion Accession Q9BXM7 Clone Number S 3135 28 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample CCCP treated HeLa, CCCP treated HEK 293 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | PINK1 |
| Synonyms | Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Mitochondrion |
| Accession | Q9BXM7 |
| Clone Number | S-3135-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | CCCP treated HeLa, CCCP treated HEK-293 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
PINK1 (PTEN-induced putative kinase 1) is a serine/threonine kinase primarily localized to mitochondria that serves as a critical sensor for mitochondrial quality control through the PINK1/Parkin mitophagy pathway; upon mitochondrial damage, PINK1 stabilizes on the outer mitochondrial membrane and phosphorylates both ubiquitin and the E3 ubiquitin ligase Parkin, initiating the selective autophagic clearance of dysfunctional mitochondria, while loss-of-function mutations in the PINK1 gene are linked to autosomal recessive early-onset Parkinson's disease, highlighting its essential role in neuronal survival and protection against neurodegeneration.
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