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Description
Caspase-8 Recombinant Rabbit mAb (S-R257)Product Specification Host Rabbit Antigen Caspase 8 Synonyms CASP 8, Apoptotic cysteine protease, Apoptotic protease Mch 5, CAP4, FADD homologous ICE ced 3 like protease, FADD like ICE, FLICE, ICE like apoptotic protease 5, MORT1 associated ced 3 homolog, MACH, MCH5 Location Cytoplasm, Nucleus Accession Q14790 Clone Number S R257 Antibody Type Recombinant mAb Application WB, ICC, ICFCM Reactivity Hu, Ms Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | Caspase-8 |
| Synonyms | CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, MCH5 |
| Location | Cytoplasm, Nucleus |
| Accession | Q14790 |
| Clone Number | S-R257 |
| Antibody Type | Recombinant mAb |
| Application | WB, ICC, ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
Background
Caspase-8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.
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