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Description
CCL4 Recombinant Rabbit mAb (S-2174-23)Product Specification Host Rabbit Antigen CCL4 Synonyms C C motif chemokine 4; G 26 T lymphocyte secreted protein; HC21; Lymphocyte activation gene 1 protein (LAG 1); MIP 1 beta(1 69); Macrophage inflammatory protein 1 beta (MIP 1 beta); LAG1; MIP1B; SCYA4 Immunogen Recombinant Protein Location Secreted Accession P13236 Clone Number S 2174 23 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0.
Product Specification
| Host | Rabbit |
| Antigen | CCL4 |
| Synonyms | C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein (LAG-1); MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta (MIP-1-beta); LAG1; MIP1B; SCYA4 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P13236 |
| Clone Number | S-2174-23 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
CCL4, also known as macrophage inflammatory protein-1β (MIP-1β), is an 8 kDa chemokine that belongs to the CC subfamily and is primarily secreted by activated T cells, macrophages, dendritic cells, and NK cells to orchestrate immune responses by binding to the G-protein-coupled receptors CCR5 and CCR8, thereby directing chemotaxis of monocytes, NK cells, and various T-cell subsets to sites of infection or inflammation, while also contributing to the pathogenesis of inflammatory diseases such as rheumatoid arthritis, HIV infection—where it competes with the virus for CCR5 binding—and certain cancers, and is further characterized by a compact tertiary structure stabilized by two disulfide bridges between conserved cysteine residues, a gene located on human chromosome 17q12, and tight regulation at transcriptional and post-transcriptional levels by cytokines like TNF-α and IL-1β.
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