SKU: 61414280144

Alexa Fluor® 488 Mouse Anti-Human TIGIT Antibody (S-R730)

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Description

Alexa Fluor® 488 Mouse Anti-Human TIGIT Antibody (S-R730)Product Specification Host Mouse Antigen TIGIT Synonyms T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing protein 9; V set and transmembrane domain containing protein 3; VSIG9; VSTM3 Location Cell membrane, Synapse Accession Q495A1 Clone Number S R730 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Purification Protein A Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer

Product Specification


Host Mouse
Antigen TIGIT
Synonyms T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3
Location Cell membrane, Synapse
Accession Q495A1
Clone Number S-R730
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Purification Protein A
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5 μl per million cells in 100μl volume

Background

TIGIT (T cell immunoglobulin and ITIM domain) is an inhibitory receptor expressed on lymphocytes, including natural killer (NK) cells and various subsets of T cells such as CD4+ T cells, CD8+ T cells, and regulatory T cells. It was discovered in 2009 through genome-wide analysis aiming to identify proteins containing domain structures typical for immunomodulatory receptors. TIGIT consists of one extracellular immunoglobulin variable domain, a type I transmembrane domain, and a short intracellular domain with one immunoreceptor tyrosine-based inhibitory motif (ITIM) and one immunoglobulin tyrosine tail (ITT)-like motif. Its main ligand is CD155, also known as poliovirus receptor (PVR), but it can also bind to CD112 and CD113 with lower affinity. TIGIT plays a significant role in down-regulating T cell and NK cell functions by interacting with these ligands expressed on antigen-presenting cells or tumor cells. This interaction inhibits immune cell responses at multiple steps of the cancer-immunity cycle, such as impairing T cell priming by dendritic cells, preventing tumor cell killing by NK cells and cytotoxic T cells, and enhancing the immune suppressive activity of regulatory T cells. Therefore, TIGIT has emerged as a major target in cancer immunotherapy. Several monoclonal antibodies that block the inhibitory activity of human TIGIT have been developed, and clinical trials are ongoing to investigate TIGIT blockade as a monotherapy or in combination with anti-PD1/PD-L1 antibodies for the treatment of patients with advanced solid malignancies.

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SKU: 61414280144

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4.6 ★★★★★
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L
Verified Purchase
Lisa Brown
Belleville, US
★★★★★ 5
Great soft pillow cases
Color: 03 - Navy, Size: Standard (20" X 26")
Pillow cases are beautiful and soft, great quality. I had to return them because standard were too small. I am going to order queen instead.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 9, 2026
J
Verified Purchase
J
New York, US
★★★★★ 5
These Bamboo Pillowcases Made Me Realize I Sleep Hot
Color: 07 - Cream, Size: Queen (20" X 30"), Color: 07 - Cream, Size: Queen (20" X 30")
I bought these mostly because I kept hearing people talk about bamboo pillowcases and honestly thought it sounded a little overhyped, but I totally get it now. The first thing I noticed was how cool they felt compared to regular cotton. I tend to get warm when I sleep and flip my pillow a million times during the night looking for the cold side, and these actually stay noticeably cooler longer. They also feel really soft without having that weird slippery texture some silky pillowcases have. My skin has been less irritated lately and my hair definitely looks less frizzy in the mornings. I have thick hair that tangles easily overnight, and these have helped more than I expected. Another thing I appreciate is that they’ve washed well so far. I was worried they’d pill or lose softness after a wash cycle, but they still feel smooth and nice. They also just make the bed feel cleaner and more comfortable overall. One of those small upgrades that ends up making a bigger difference than you’d think.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 2, 2026
A
Verified Purchase
Aquamac
Chelsea, US
★★★★★ 5
Soft and cooling
Color: 08 - Sage Green, Size: Queen (20" X 30")
These are great pillowcases. Very soft, comfortable, and they stay cool throughout the night. They fit perfectly and feel really nice against your skin.
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Reviewed in the United States on May 21, 2026
A
Verified Purchase
Ashley Hile
Lexington, US
★★★★★ 4
Sheets are good. Greens don't match
Color: 08 - Sage Green, Size: King (20" X 36"), Color: 08 - Sage Green, Size: King (20" X 36")
I purchased the sage green sheets to go along with another Bedsure comforter, then purchased 2 more pillow cases (because i I like a lot of pillows) and the greens don't exactly match. This doesn't REALLY bother me as I feel like its fine with a little "texture." Sheets feel nice and light and I love the look of it in my room.
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Reviewed in the United States on March 3, 2026
A
Verified Purchase
Apple
Boise, US
★★★★★ 5
Good buy Pillowcases
Color: 08 - Sage Green, Size: King (20" X 36")
I bought these Bedsure king-size pillowcases from Amazon and overall I’m very happy with them. The first thing I noticed was how incredibly soft and smooth the fabric feels. They almost feel silky, which makes them very comfortable to sleep on. When you lay your head down, the material feels cool and gentle on the skin, which I really like. I also appreciate the zipper closure. It keeps the pillow securely inside the case and makes everything look neat and tidy on the bed. The zipper is hidden well and doesn’t feel bulky or uncomfortable. The only small downside is that the pillowcases are so smooth that the pillows can sometimes slide around or even slip off the bed a little. However, that’s really just because the material is so silky. Overall, I would still recommend these pillowcases. They are soft, comfortable, and feel like a nice upgrade compared to regular pillowcases.
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Reviewed in the United States on March 8, 2026

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