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Description
NeuroD2 Recombinant Rabbit mAb (S-3092-64)Product Specification Host Rabbit Antigen NeuroD2 Synonyms Neurogenic differentiation factor 2; Class A basic helix loop helix protein 1 (bHLHa1); NeuroD related factor (NDRF); BHLHA1; NDRF; NEUROD2 Immunogen Synthetic Peptide Location Nucleus Accession Q15784 Clone Number S 3092 64 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample mouse cerebellum, mouse brain, rat cerebellum, rat brain
Product Specification
| Host | Rabbit |
| Antigen | NeuroD2 |
| Synonyms | Neurogenic differentiation factor 2; Class A basic helix-loop-helix protein 1 (bHLHa1); NeuroD-related factor (NDRF); BHLHA1; NDRF; NEUROD2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q15784 |
| Clone Number | S-3092-64 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse cerebellum, mouse brain, rat cerebellum, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms |
| IF | 1:500 | Ms |
Background
NeuroD2 is a neuron-specific basic helix-loop-helix transcription factor that drives cortical projection neuron differentiation, radial migration and layer-specific identity by directly activating genes like Cdk5r1, Lrp8, Fezf2 and Satb2, while it fine-tunes store-operated Ca²⁺ entry by repressing STIM1, and its deletion disrupts thalamocortical barrel map formation, reduces excitability and produces autism-like motor and seizure phenotypes.
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