Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 28 - Sep 2
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Desmoglein 3 Recombinant Rabbit mAb (SDT-3213-33)Product Specification Host Rabbit Antigen Desmoglein 3 Synonyms Desmoglein 3; 130 kDa pemphigus vulgaris antigen (PVA); Cadherin family member 6; CDHF6; DSG3 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P32926 Clone Number SDT 3213 33 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A431, HaCaT Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Desmoglein 3 |
| Synonyms | Desmoglein-3; 130 kDa pemphigus vulgaris antigen (PVA); Cadherin family member 6; CDHF6; DSG3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P32926 |
| Clone Number | SDT-3213-33 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | A431, HaCaT |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
Background
Desmoglein-3 (Dsg3) is a calcium-dependent transmembrane glycoprotein and a key component of desmosomes, specialized cell-cell adhesion structures primarily found in stratified squamous epithelia such as the skin and oral mucosa; it functions to maintain tissue integrity by anchoring intermediate filaments of the cytoskeleton to sites of intercellular contact, and beyond its structural role, Dsg3 actively regulates epithelial homeostasis by suppressing p53-mediated stress responses, thereby acting as an anti-stress protein that protects keratinocytes from apoptosis induced by UVB, mechanical stress, or genotoxic agents, while also promoting cancer cell migration and invasion through activation of the AP-1 transcription factor and PKC-dependent phosphorylation of ezrin, and its autoimmune targeting by autoantibodies results in the loss of adhesion and blister formation characteristic of pemphigus vulgaris, making Dsg3 a central player in both physiological epithelial cohesion and pathological processes including cancer metastasis and autoimmune blistering diseases.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy