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Description
Frizzled-4/FZD4 His Tag Protein, HumanProduct Specification Species Human Synonyms hFz4, FzE4, CD344, Frizzled 4, Fz 4, EVR1, CD344, FZD4S, FEVR, GPCR Accession Q9ULV1 Amino Acid Sequence Phe37 Glu180, with C terminal 8*His FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEEGGGSHHHHHHHH Expression System HEK293 Molecular Weight 20 28kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation
Product Specification
| Species | Human |
| Synonyms | hFz4, FzE4, CD344, Frizzled 4, Fz-4, EVR1, CD344, FZD4S, FEVR, GPCR |
| Accession | Q9ULV1 |
| Amino Acid Sequence | Phe37-Glu180, with C-terminal 8*His FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEEGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 20-28kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Nallathambi J. et al. (2006) Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy. Mol Vis. 12: 1086-1092. 2、Sjöblom T. et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science. 314(5797): 268-274. |
Background
Frizzled-4, designated CD344, is a 7-transmembrane glycoprotein of the Frizzled family within the G-protein coupled receptor superfamily. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as planar cell polarity and calcium flux pathways. Frizzled-4 is particularly important in angiogenic Wnt pathway signaling. Frizzled4 plays a crucial role in maintaining the integrity of the blood-brain barrier/blood-eye barrier, and regulating the expression of related proteins in the Frizzled4/Norrin pathway can regulate the switching of the blood-brain/blood-eye barrier. Frizzled-4 plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP).
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4.4 ★★★★★
Based on 27 reviews
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Product Reviews
★★★★★ 5
Love them
Color: Black, Size: Standard
I LOVE THESE PILLOW CASES. I love the zipper so it stays on the pillow, how it stays cool, and the fabric. Worth it 100%
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Reviewed in the United States on June 5, 2026
★★★★★ 5
BUY IT!!
Color: Light Gray, Size: Standard
Love the material super soft and smooth like silk. It’s also nice and cold for when I got to bed! Definitely recommend
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Reviewed in the United States on June 3, 2026
★★★★★ 5
Actually feels cool at night
Color: Light Gray, Size: Standard
I’ve been using these for several days now and I did notice a difference. I tend to get hot while sleeping, so I was curious if they would actually help, and they do feel cool when you lay on them. I also like that they’re soft and comfortable, not that weird texture some “cooling” products have. So far, I’ve been really happy with them.
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Reviewed in the United States on May 23, 2026
★★★★★ 5
Definitely recommend
Color: White, Size: Queen (20" X 30")
I highly recommend this pillow case. With two sides it is easy to stay comfortable as the weather changes. The cooling side is nicely cool to touch and both sides are incredibly soft. The size is also good.
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Reviewed in the United States on May 26, 2026
★★★★★ 5
Nice & cool
Color: Beige, Size: King (20" X 36")
These are the best pillowcases! I love having a cooling side for summer and a warm side for winter. I can't imagine switching back to normal cotton pillowcases after using these. They zip on so they stay on unlike regular pillowcases.
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Reviewed in the United States on May 11, 2026