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Description
SFXN1/TCC Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SFXN1 TCC Synonyms Sideroflexin 1; Sfxn1 Immunogen Recombinant Protein Location Mitochondrion Accession Q99JR1 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample PC 3, LNCaP, MCF7, HepG2, NIH 3T3, mouse brain, C6, rat brain, COS 7 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | SFXN1/TCC |
| Synonyms | Sideroflexin-1; Sfxn1 |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion |
| Accession | Q99JR1 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | PC-3, LNCaP, MCF7, HepG2, NIH/3T3, mouse brain, C6, rat brain, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
SFXN1/TCC (sideroflexin-1/tricarboxylate carrier) is an ~35 kDa integral inner-mitochondrial-membrane protein that functions as a metabolite transporter, exporting mitochondrial acetyl-CoA to the cytosol for lipogenesis and importing serine (and possibly tricarboxylates or iron-related substrates) into the matrix to support one-carbon metabolism, heme/iron–sulfur biogenesis and redox balance, with mutations causing flexed-tail anemia and mitochondrial iron overload in mice and implicating the carrier in human metabolic and neurodegenerative disorders.
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