SKU: 6469880279

PE Mouse Anti-human HLA-ABC Antibody (S-R526)

Sale price$85.50 Regular price$95.00
Save 10%

Pay in installments of $23.75 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 27 - Sep 1

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

PE Mouse Anti-human HLA-ABC Antibody (S-R526)Product Specification Host Mouse Antigen HLA ABC Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA B); HLA class I histocompatibility antigen, C alpha chain; HLA Cw; Human leukocyte antigen C Location Cell membrane Accession P04439P01889P10321 Clone Number S R526 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM

Product Specification


Host Mouse
Antigen HLA-ABC
Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA-A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA-B); HLA class I histocompatibility antigen, C alpha chain; HLA-Cw; Human leukocyte antigen C
Location Cell membrane
Accession P04439、P01889、P10321
Clone Number S-R526
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood Leukocytes
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

HLA-ABC (also termed HLA class I classical heavy chains A, B, and C) are 44 kDa type I transmembrane glycoproteins encoded within the major histocompatibility complex on chromosome 6p21.3; each non-covalently associates with the invariant light chain β2-microglobulin (12 kDa) to form a peptide-binding heterodimer that is constitutively expressed on nearly all nucleated cells. These molecules serve as the principal conduit for presenting endogenously derived 8–11-mer peptides to CD8⁺ cytotoxic T lymphocytes, thereby orchestrating immune surveillance against intracellular pathogens, tumors, and transplanted tissues. Polymorphic residues concentrated in the α1 and α2 domains create an extraordinary diversity (thousands of alleles catalogued in the IPD-IMGT/HLA database), which underpins population-level resistance to infection yet constitutes the primary barrier to solid-organ and hematopoietic stem-cell transplantation through allorecognition. Beyond antigen presentation, HLA-ABC interacts with NK-cell inhibitory receptors (KIR and LILRB1) to calibrate natural killer cell responses, and its surface levels are dynamically modulated by cytokines such as interferon-γ, viral immune evasion proteins (e.g., HIV Nef, CMV US2/US11), and oncogenic signaling pathways, making quantitative HLA-ABC expression a prognostic biomarker in cancer immunotherapy.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 6469880279

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.1 ★★★★★
Based on 16 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
T
Verified Purchase
Tom
Birmingham, US
★★★★★ 5
Perfect fit
Nice quality
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 10, 2025
N
Verified Purchase
Niju Varghese
Battle Creek, US
★★★★★ 5
A Breath of Fresh Air for Your Car
Size: 8.3" x 9.3" x 1.3"
This BOSCH 6037C HEPA Cabin Air Filter is a fantastic and simple upgrade for your vehicle. It delivers exactly what it promises: cleaner, fresher air inside your car. The installation was incredibly straightforward. It was a perfect fit for my Acura RDX, and I was able to swap out the old filter in just a few minutes. You don't need any special tools, making this an easy and quick DIY project for anyone. The difference in air quality is immediately noticeable. The HEPA filtration does a great job of trapping dust, pollen, and other allergens, leaving the cabin air feeling much cleaner. It also seems to reduce outside odors, which is a huge plus. Overall, this is a high-quality product that provides excellent value. It's an essential and affordable way to improve the air quality in your car. I highly recommend it for any compatible Honda or Acura model.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 1, 2025
B
Verified Purchase
B M
Whiting, US
★★★★★ 5
High quality cabin filter
Size: 8.3" x 9.3" x 1.3"
I change out the cabin filters in my cars at every oil change. It help when running the A/C all summer. This is high quality cabin filter that does its job. Seeing what the dealer wants for literally 1 minute worth of work is silly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2026
A
Verified Purchase
AmazonBuyer
Belleville, US
★★★★★ 5
It works as expected
Size: 8.3" x 9.3" x 1.3"
Great. It does block air flow by a bit, but it is ok, if you don't need strong air blowing your face at maximum setting all the time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 14, 2025
T
Verified Purchase
ThomasD
Alexandria, US
★★★★★ 5
Great cabin filter for 2019 Acura RDX
Size: 8.3" x 9.3" x 1.3"
When I have my car serviced at the Acura dealership, they routinely recommend that the cabin filter be replaced. As we all know, a dealership is going to charge an arm and a leg for a basic service. Therefore, I have been replacing the cabin air filter myself for the past few years. I like BOSCH products and when I found this filter on Amazon, I knew that was the one to purchase for my 2019 Acura RDX. The filter fits perfectly in its location in the glove box. It literally takes less than five minutes to swap out the old filter for the new. I will continue to use this product while I have the RDX.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 30, 2025

recommand products