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Description
GM-CSFR α His Tag Protein, HumanProduct Specification Species Human Synonyms GMR, CD116, CSF2R, SMDP4, CSF2RAX, CSF2RAY, CSF2RX, SMDP4 Accession P15509 Amino Acid Sequence Glu23 Gly320, with C 8*His Expression System HEK293 Molecular Weight 55 70kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after
Product Specification
| Species | Human |
| Synonyms | GMR, CD116, CSF2R, SMDP4, CSF2RAX, CSF2RAY, CSF2RX, SMDP4 |
| Accession | P15509 |
| Amino Acid Sequence | Glu23-Gly320, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Prevost J M. et al. (2002) Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Inflammatory Stimuli Up-Regulate Secretion of the Soluble GM-CSF Receptor in Human Monocytes: Evidence for Ectodomain Shedding of the Cell Surface GM-CSF Receptor α Subunit. J Immunol. 169(10): 5679-5688. 2、Cao Y. et al. (2007) Angiogenesis modulates adipogenesis and obesity. J Clin Invest. 117(9): 2362-2368. 3、Fleetwood A J. et al. (2005) Functions of Granulocyte-Macrophage Colony-Stimulating Factor. Crit Rev Immunol. 25(5): 405-428. |
Background
GM-CSF receptor alpha is a member of the cytokine family of receptors. GM-CSF receptor alpha is found in the pseudoautosomal region of the X and Y chromosomes. GM-CSF receptor alpha has different isoform, with some of the isoforms being membrane-bound and others being soluble. Soluble GM-CSF receptor alpha subunit is a soluble isoform of the GMR alpha that is believed to arise exclusively through alternative splicing of the GMR alpha gene product. The sGMR alpha mRNA is expressed in a variety of tissues, but it is not clear which cells are capable of secreting the protein. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in GM-CSF receptor alpha, which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages. While no pharmacologic therapy currently exists for hPAP, it was recently demonstrated that endotracheal instillation of wild-type or gene-corrected mononuclear phagocytes results in a significant and durable therapeutic efficacy in a validated murine model of hPAP.
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4.5 ★★★★★
Based on 30 reviews
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Product Reviews
★★★★★ 5
Just the DSM-5 tool I was looking for
Format: Paperback
I searched for a DSM-5 quick reference tool that I could use throughout my workday. This DSM-5 book by Medical Creations was just what I was looking for. Each psychiatric condition is listed in an easy-to-find and easy-to-read format. Diagnostic criteria are summarized in a bulleted format. I found the listed corresponding ICD-10 code especially useful when charting patient notes.
I found the final chapter especially interesting, as I was unfamiliar with many of the covered conditions. Chapter 20 is titled "Cultural Diagnoses and Conditions for Further Study, Interviewing". This chapter includes disorders such as caffeine use disorder and internet gaming disorder.
The book is lightweight and nicely fits into a white coat pocket. It is a great resource for both students who are just learning about psychiatric conditions and for experienced healthcare providers. I highly recommend!
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Reviewed in the United States on April 22, 2025
★★★★★ 5
Great resource
Format: Paperback
Great resource for clinicians
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Reviewed in the United States on January 17, 2026
★★★★★ 5
Review from a Registered Nurse
Format: Paperback
The DSM-5-TR Desk Reference from Medical Creations is a fantastic addition to my professional resources. It arrived quickly and was surprisingly affordable for its quality. Despite being paperback, the durable cover promises longevity, making it a reliable companion for years to come.
The book's size is perfect for quick consultations and fits neatly on any bookshelf. The writing is clear and professional, striking a balance that's both informative and accessible.
The layout is intuitive, facilitating easy navigation and swift access to specific details. Clear fonts and consistent formatting enhance readability throughout.
Overall, this desk reference is a fantastic resource for mental health professionals. Its concise format is a practical solution to the bulkiness of the full DSM-5-TR, ensuring essential information is always at hand. Highly recommended!
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Reviewed in the United States on April 11, 2025
★★★★★ 5
Concise and easy to use
Format: Paperback
This is a great companion to the full DSM-5-TR!
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Reviewed in the United States on December 29, 2025
★★★★★ 4
Interesting book.
Format: Paperback
No more surprise very useful book. You can even use it and ask clients about their symptoms to confirm the suspected diagnosis.
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Reviewed in the United States on October 26, 2025