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Description
BCAR1 Recombinant Rabbit mAb (S-3542-49)Product Specification Host Rabbit Antigen BCAR1 Synonyms Breast cancer anti estrogen resistance protein 1; CRK associated substrate; Cas scaffolding protein family member 1; p130cas; CAS; CASS1; CRKAS Immunogen Recombinant Protein Location Cytoplasm Accession P56945 Clone Number S 3542 49 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, HepG2, A431, NIH 3T3, C6 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | BCAR1 |
| Synonyms | Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; Cas scaffolding protein family member 1; p130cas; CAS; CASS1; CRKAS |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | P56945 |
| Clone Number | S-3542-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HepG2, A431, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
BCAR1 (Breast Cancer Anti-Estrogen Resistance 1), also known as p130Cas (Crk-associated substrate), is a multifunctional adaptor/scaffold protein that plays a pivotal role in integrating signals from integrins, growth factor receptors, and other cellular stimuli to regulate cell adhesion, migration, proliferation, and survival. Structurally, BCAR1 contains an N-terminal SH3 domain, a proline-rich region, a large substrate domain with multiple YxxP motifs that serve as phosphorylation sites for Src family kinases, and a C-terminal focal adhesion targeting (FAT) domain that mediates its localization to focal adhesions through interactions with paxillin and other proteins. Upon tyrosine phosphorylation, BCAR1 acts as a docking platform for various signaling molecules including Crk, Nck, and PI3K, thereby activating downstream pathways such as Ras-MAPK and PI3K-AKT that promote cytoskeletal reorganization and oncogenic transformation. Aberrant overexpression or hyperactivation of BCAR1 has been strongly implicated in tumor progression, metastasis, and resistance to endocrine therapies in breast cancer and other malignancies, making it a potential prognostic biomarker and therapeutic target.
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