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Description
SOCS3 Recombinant Rabbit mAb (S-2238-34)Product Specification Host Rabbit Antigen SOCS3 Synonyms Suppressor of cytokine signaling 3; SOCS 3; Cytokine inducible SH2 protein 3 (CIS 3); STAT induced STAT inhibitor 3 (SSI 3); CIS3; SSI3 Immunogen Recombinant Protein Location Cytoplasm Accession O14543 Clone Number S 2238 34 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample HeLa, Ramos, Jurkat, RAW264. 7 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | SOCS3 |
| Synonyms | Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3 (CIS-3); STAT-induced STAT inhibitor 3 (SSI-3); CIS3; SSI3 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | O14543 |
| Clone Number | S-2238-34 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, Ramos, Jurkat, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
SOCS3 (Suppressor of Cytokine Signaling 3) is a critical regulator of cytokine signaling pathways. It is an intracellular protein that plays a key role in modulating immune responses and maintaining homeostasis. SOCS3 primarily functions by inhibiting the JAK-STAT signaling pathway, a crucial pathway activated by various cytokines such as interleukins and interferons. By binding to activated JAKs (Janus kinases) and preventing their phosphorylation of downstream targets like STAT proteins, SOCS3 effectively dampens the signaling cascade, thereby controlling the intensity and duration of cytokine-mediated effects. Its expression is often induced by cytokines themselves, creating a negative feedback loop that helps prevent excessive immune activation. Dysregulation of SOCS3 has been implicated in several diseases, including chronic inflammation and autoimmune disorders, highlighting its importance in maintaining proper immune function and overall health.
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4.4 ★★★★★
Based on 21 reviews
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Product Reviews
★★★★★ 4
Fantastic style, good stability, customizable finish, and great customer service
Size: M Desk Unfinished 3/4-in and 1/2-in
Put this together in about April 2020 right about the crazy lockdown/quarantine/work-from-home timeframe. I knew that I wanted a simple hardwood desk with no drawers or stuff below the top. I have an ergonomic keyboard tray that I have attached to all my work desks for many years now, and it was too long for my old home desk, which was also made of MDF and was falling apart. Boo.
Enter this kit plus a butcher block top from the big box store. This kit went together easily. I had lost the instructions but a quick email to the JS Supplies company, and they hooked me up. By the time they sent it, I had actually figured out the part that was puzzling, which was what the all-thread pieces were for (the couplers between the elbows and the flanges on the top side).
I degreased all the parts with a simple Simple Green-type solution diluted in a 5 gallon bucket. I then sprayed the pieces with a satin nitrocellulose laqcuer (Minwax brand that I got from the home improvement big box). Worked great. I thought about doing a sealed rust finish using a science project volcano--vinegar and baking soda for a quick layer of rust on the outside--but I decided against it, as I wasn't sure of how stable the final product would be, even after a clear spray finish. The satin nitro finish looks great without even looking like a finish. I also coated the pieces with paste wax after the finish dried, just for good measure.
The one thing that is a bit disappointing is the stability... WITH MY TOP, mind you.I should be clear that the top that I'm using is a 1-3/4" thick monster piece of birch butcher block that is 60" x 30". I'm guessing that it's 40-50 pounds? Maybe more. This is probably WAY more weight than this leg set is made for. I also have the aforementioned keyboard tray that sticks out (torque equals force times lever arm) and causes even more torque. I get some shaking with the top with this setup. I have the desk on carpet; I was concerned that maybe the carpet and pad were not giving enough stability with the feet, so I made some plywood platforms for the feet. I also carefully leveled the feet to make sure it wasn't just uneven legs that was causing the instability. Still shakes no matter what I tried.
I think it's just that I have such a heavy top--more than this thing is spec'd for. That's totally fine, and I don't want to knock off a bunch of stars for that. I leave these comments more as a "don't do what I did" thing. Just be advised that you need to limit the weight of the top to something reasonable.
The design of one upright on each side of the desk with a pipe coupler in between is probably the weak spot with my heavy desktop; I'm thinking of either adding tension on either side (with some threaded rod and turnbuckles) or some extra supports with something like the Steel-Tek pieces from Lowe's.
Overall, I'm very satisfied with the product and the company!
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Reviewed in the United States on June 23, 2020
★★★★★ 5
So nice I bought twice!
Size: H Desk Unfinished 3/4-in and 1/2-in, Size: H Desk Unfinished 3/4-in and 1/2-in
For starters, this is a great buy if it is exactly what you want. For me that was the case and it would have cost me a good $40 or more to replicate it at a big box store. With that said, if you are not planning on using all of the pieces and want a different configuration, this may not be the kit for you. All of the parts inside are just like if you bought it at a local home improvement store. All the pipes need to be cleaned and protected. I personally found that dish soap (dry off immediately after you clean a piece) was the easiest to clean everything and I finished it with some wax. The kit is sturdy and easily supports the weight of my butcher block tops. I inverted the kit as it is designed as I intend on adding a shelf and am planning on using the support brace to aid in holding that shelf up for cable management. After cleaning and protecting, putting the kit together only took 5-10 minutes and that was with kid disruptions. I purchased 2 so that my wife and I could have matching desks in the office and I couldn't be happier.
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Reviewed in the United States on August 23, 2019
★★★★★ 5
Durable and sturdy. I bought two
Size: H Desk Unfinished 3/4-in and 1/2-in
Love the kit. I ordered two to make an L-shaped desk for my home office. Perfect height, looks cool, and sturdy. Slightly tricky to get two of them to the exact same height but you can adjust them buy loosing/tightning parts. Way cheaper than going to the hardware store and buying the same parts. I wiped each piece down as they are a bit dirty/greasy, but no big deal.
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Reviewed in the United States on August 9, 2021
★★★★★ 5
Great legs - sturdy when fully assembled with tabletop.
Size: H Desk Unfinished 3/4-in and 1/2-in
These legs are great. I put it together with a butcher block tabletop and it turned out beautifully. I recommend using a level on the legs once you get them into position and again when you place a top on it. The screws included were so easy to screw into the block but that will vary depending on the top you select. Watch the videos another reviewer posted on cleaning the legs with a mild soapy water and dry them thoroughly. It really helped me. Also after it was all assembled I used a clear acrylic - in a spray can to clear coat and seal the legs. I am really happy with it.
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Reviewed in the United States on July 4, 2020
★★★★★ 5
Love my center table
Color: Black-new, Material Type: Glass
Beautiful beautiful beautiful 😍😍😍😍 easy to setup, functional fit the space well could be a bit thicker for but it is ok
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Reviewed in the United States on February 5, 2026